Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912054299> ?p ?o ?g. }
- W2912054299 endingPage "723" @default.
- W2912054299 startingPage "713" @default.
- W2912054299 abstract "Introduction: Uterine leiomyosarcomas (ULMS) account for 1% of all uterine malignancies and for 30% of all uterine sarcomas. The preoperative diagnosis of ULMS is challenging for the physicians, as the symptoms of these tumors are often vague and nonspecific. Moreover, as ULMS have an aggressive biologic behavior, affected women frequently have very poor prognosis.Areas covered: The aim of this review is to describe the current pharmacotherapy for ULMS, including the ongoing clinical trials.Expert opinion: Surgery is the standard treatment for patients with early-stage ULMS. In this setting, the role of adjuvant therapies is still unclear. In the case of advanced, persistent, or recurrent ULMS, chemotherapy is the standard care with the most frequently used drug being doxorubicin. As the outcomes for patients with the currently available conventional single or combined regimens are far from being satisfactory, new alternative and innovative medical compounds have or are being evaluated. Recently, pazopanib, and olaratumab, two innovative targeted drugs, have been approved by the Food and Drug Administration (FDA) for treating advanced soft-tissue sarcoma, including ULMS. However, further clinical investigations into new and innovation therapeutic options are warranted." @default.
- W2912054299 created "2019-02-21" @default.
- W2912054299 creator A5033337879 @default.
- W2912054299 creator A5035757408 @default.
- W2912054299 creator A5042301284 @default.
- W2912054299 creator A5043949836 @default.
- W2912054299 creator A5046855515 @default.
- W2912054299 creator A5081853149 @default.
- W2912054299 creator A5091133692 @default.
- W2912054299 date "2019-02-06" @default.
- W2912054299 modified "2023-10-17" @default.
- W2912054299 title "Current state of the art and emerging pharmacotherapy for uterine leiomyosarcomas" @default.
- W2912054299 cites W1489305676 @default.
- W2912054299 cites W1528500075 @default.
- W2912054299 cites W1593008823 @default.
- W2912054299 cites W1608710587 @default.
- W2912054299 cites W1955072209 @default.
- W2912054299 cites W1965498557 @default.
- W2912054299 cites W1970717007 @default.
- W2912054299 cites W1972325995 @default.
- W2912054299 cites W1975320260 @default.
- W2912054299 cites W1991618187 @default.
- W2912054299 cites W1997197477 @default.
- W2912054299 cites W2000933024 @default.
- W2912054299 cites W2001564888 @default.
- W2912054299 cites W2021377616 @default.
- W2912054299 cites W2022188012 @default.
- W2912054299 cites W2022905122 @default.
- W2912054299 cites W2029612031 @default.
- W2912054299 cites W2029758372 @default.
- W2912054299 cites W2030541266 @default.
- W2912054299 cites W2031391627 @default.
- W2912054299 cites W2033168622 @default.
- W2912054299 cites W2034275482 @default.
- W2912054299 cites W2054993302 @default.
- W2912054299 cites W2055183928 @default.
- W2912054299 cites W2073672572 @default.
- W2912054299 cites W2077295631 @default.
- W2912054299 cites W2082063053 @default.
- W2912054299 cites W2082479412 @default.
- W2912054299 cites W2091675222 @default.
- W2912054299 cites W2096755839 @default.
- W2912054299 cites W2101776780 @default.
- W2912054299 cites W2107230638 @default.
- W2912054299 cites W2110891275 @default.
- W2912054299 cites W2112169652 @default.
- W2912054299 cites W2117905001 @default.
- W2912054299 cites W2119679072 @default.
- W2912054299 cites W2123036742 @default.
- W2912054299 cites W2127905742 @default.
- W2912054299 cites W2129842361 @default.
- W2912054299 cites W2130749589 @default.
- W2912054299 cites W2140292293 @default.
- W2912054299 cites W2144530818 @default.
- W2912054299 cites W2155537485 @default.
- W2912054299 cites W2155597252 @default.
- W2912054299 cites W2158644353 @default.
- W2912054299 cites W2161170571 @default.
- W2912054299 cites W2167352270 @default.
- W2912054299 cites W2175239727 @default.
- W2912054299 cites W2179832015 @default.
- W2912054299 cites W2236777922 @default.
- W2912054299 cites W2289495176 @default.
- W2912054299 cites W2305520422 @default.
- W2912054299 cites W2320965040 @default.
- W2912054299 cites W2387879652 @default.
- W2912054299 cites W2413552560 @default.
- W2912054299 cites W2465632965 @default.
- W2912054299 cites W2508532926 @default.
- W2912054299 cites W2508912450 @default.
- W2912054299 cites W2514114301 @default.
- W2912054299 cites W2545879467 @default.
- W2912054299 cites W2560301905 @default.
- W2912054299 cites W2588395027 @default.
- W2912054299 cites W2591493010 @default.
- W2912054299 cites W2592559255 @default.
- W2912054299 cites W2593298761 @default.
- W2912054299 cites W2603749671 @default.
- W2912054299 cites W2610035536 @default.
- W2912054299 cites W2731817066 @default.
- W2912054299 cites W2751505649 @default.
- W2912054299 cites W2752560124 @default.
- W2912054299 cites W2758964239 @default.
- W2912054299 cites W2763975305 @default.
- W2912054299 cites W2775816941 @default.
- W2912054299 cites W2794582015 @default.
- W2912054299 cites W2883910697 @default.
- W2912054299 cites W2891531638 @default.
- W2912054299 cites W2896109871 @default.
- W2912054299 cites W2900527803 @default.
- W2912054299 cites W4231814132 @default.
- W2912054299 cites W4233897861 @default.
- W2912054299 doi "https://doi.org/10.1080/14656566.2019.1571042" @default.
- W2912054299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30724615" @default.
- W2912054299 hasPublicationYear "2019" @default.
- W2912054299 type Work @default.
- W2912054299 sameAs 2912054299 @default.
- W2912054299 citedByCount "11" @default.