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- W2912055351 endingPage "110" @default.
- W2912055351 startingPage "110" @default.
- W2912055351 abstract "The available data, including experimental studies, clearly indicate an excessive intravascular activation of circulating platelets in multiple sclerosis (MS) and their hyper-responsiveness to a variety of physiological activators. Platelet activation is manifested as an increased adhesion and aggregation and is accompanied by the formation of pro-thrombotic microparticles. Activated blood platelets also show an expression of specific membrane receptors, synthesis many of biomediators, and generation of reactive oxygen species. Epidemiological studies confirm the high risk of stroke or myocardial infarction in MS that are ischemic incidents, strictly associated with incorrect platelet functions and their over pro-thrombotic activity. Chronic inflammation and high activity of pro-oxidative processes in the course of MS are the main factors identified as the cause of excessive platelet activation. The primary biological function of platelets is to support vascular integrity, but the importance of platelets in inflammatory diseases is also well documented. The pro-thrombotic activity of platelets and their inflammatory properties play a part in the pathophysiology of MS. The analysis of platelet function capability in MS could provide useful information for studying the pathogenesis of this disease. Due to the complexity of pathological processes in MS, medication must be multifaceted and blood platelets can probably be identified as new targets for therapy in the future." @default.
- W2912055351 created "2019-02-21" @default.
- W2912055351 creator A5033678080 @default.
- W2912055351 creator A5060187731 @default.
- W2912055351 creator A5088826366 @default.
- W2912055351 date "2019-02-01" @default.
- W2912055351 modified "2023-10-17" @default.
- W2912055351 title "Pro-Thrombotic Activity of Blood Platelets in Multiple Sclerosis" @default.
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