FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912057212> ?p ?o ?g. }

• W2912057212 endingPage "632" @default.
• W2912057212 startingPage "627" @default.
• W2912057212 abstract "Acid-sensing ion channels (ASICs) are a family of ion channels permeable to cations and largely responsible for the onset of acid-evoked ion currents both in neurons and in different types of cancer cells, thus representing a potential target for drug discovery. Owing to the limited attention ASIC2 has received so far, an exploratory program was initiated to identify ASIC2 inhibitors using diminazene, a known pan-ASIC inhibitor, as a chemical starting point for structural elaboration. The performed exploration enabled the identification of a novel series of ASIC2 inhibitors. In particular, compound 2u is a brain penetrant ASIC2 inhibitor endowed with an optimal pharmacokinetic profile. This compound may represent a useful tool to validate in animal models in vivo the role of ASIC2 in different neurodegenerative central nervous system pathologies." @default.
• W2912057212 created "2019-02-21" @default.
• W2912057212 creator A5000702860 @default.
• W2912057212 creator A5003742541 @default.
• W2912057212 creator A5003778035 @default.
• W2912057212 creator A5009611583 @default.
• W2912057212 creator A5021103556 @default.
• W2912057212 creator A5035380702 @default.
• W2912057212 creator A5039122162 @default.
• W2912057212 creator A5044099332 @default.
• W2912057212 creator A5047090164 @default.
• W2912057212 creator A5047333361 @default.
• W2912057212 creator A5050966293 @default.
• W2912057212 creator A5060967795 @default.
• W2912057212 creator A5070848001 @default.
• W2912057212 creator A5073140713 @default.
• W2912057212 creator A5085304880 @default.
• W2912057212 creator A5091743802 @default.
• W2912057212 date "2019-02-07" @default.
• W2912057212 modified "2023-09-24" @default.
• W2912057212 title "Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS" @default.
• W2912057212 cites W1506502811 @default.
• W2912057212 cites W2011240126 @default.
• W2912057212 cites W2025949383 @default.
• W2912057212 cites W2029735354 @default.
• W2912057212 cites W2043777410 @default.
• W2912057212 cites W2045265824 @default.
• W2912057212 cites W2061633953 @default.
• W2912057212 cites W2085805107 @default.
• W2912057212 cites W2088956694 @default.
• W2912057212 cites W2096293984 @default.
• W2912057212 cites W2130630814 @default.
• W2912057212 cites W2145360888 @default.
• W2912057212 cites W2167396539 @default.
• W2912057212 cites W2168746329 @default.
• W2912057212 cites W2225181322 @default.
• W2912057212 cites W2330543810 @default.
• W2912057212 cites W2508097989 @default.
• W2912057212 cites W2529039609 @default.
• W2912057212 cites W2599882869 @default.
• W2912057212 cites W2756323897 @default.
• W2912057212 cites W2764115850 @default.
• W2912057212 cites W2791681345 @default.
• W2912057212 cites W2801886783 @default.
• W2912057212 cites W2804501766 @default.
• W2912057212 doi "https://doi.org/10.1021/acsmedchemlett.8b00591" @default.
• W2912057212 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6466820" @default.
• W2912057212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30996808" @default.
• W2912057212 hasPublicationYear "2019" @default.
• W2912057212 type Work @default.
• W2912057212 sameAs 2912057212 @default.
• W2912057212 citedByCount "1" @default.
• W2912057212 countsByYear W29120572122023 @default.
• W2912057212 crossrefType "journal-article" @default.
• W2912057212 hasAuthorship W2912057212A5000702860 @default.
• W2912057212 hasAuthorship W2912057212A5003742541 @default.
• W2912057212 hasAuthorship W2912057212A5003778035 @default.
• W2912057212 hasAuthorship W2912057212A5009611583 @default.
• W2912057212 hasAuthorship W2912057212A5021103556 @default.
• W2912057212 hasAuthorship W2912057212A5035380702 @default.
• W2912057212 hasAuthorship W2912057212A5039122162 @default.
• W2912057212 hasAuthorship W2912057212A5044099332 @default.
• W2912057212 hasAuthorship W2912057212A5047090164 @default.
• W2912057212 hasAuthorship W2912057212A5047333361 @default.
• W2912057212 hasAuthorship W2912057212A5050966293 @default.
• W2912057212 hasAuthorship W2912057212A5060967795 @default.
• W2912057212 hasAuthorship W2912057212A5070848001 @default.
• W2912057212 hasAuthorship W2912057212A5073140713 @default.
• W2912057212 hasAuthorship W2912057212A5085304880 @default.
• W2912057212 hasAuthorship W2912057212A5091743802 @default.
• W2912057212 hasBestOaLocation W29120572122 @default.
• W2912057212 hasConcept C104317684 @default.
• W2912057212 hasConcept C143928317 @default.
• W2912057212 hasConcept C150903083 @default.
• W2912057212 hasConcept C169760540 @default.
• W2912057212 hasConcept C170493617 @default.
• W2912057212 hasConcept C185592680 @default.
• W2912057212 hasConcept C207001950 @default.
• W2912057212 hasConcept C2989108626 @default.
• W2912057212 hasConcept C50254741 @default.
• W2912057212 hasConcept C53345823 @default.
• W2912057212 hasConcept C55493867 @default.
• W2912057212 hasConcept C70721500 @default.
• W2912057212 hasConcept C74187038 @default.
• W2912057212 hasConcept C86803240 @default.
• W2912057212 hasConcept C98274493 @default.
• W2912057212 hasConceptScore W2912057212C104317684 @default.
• W2912057212 hasConceptScore W2912057212C143928317 @default.
• W2912057212 hasConceptScore W2912057212C150903083 @default.
• W2912057212 hasConceptScore W2912057212C169760540 @default.
• W2912057212 hasConceptScore W2912057212C170493617 @default.
• W2912057212 hasConceptScore W2912057212C185592680 @default.
• W2912057212 hasConceptScore W2912057212C207001950 @default.
• W2912057212 hasConceptScore W2912057212C2989108626 @default.
• W2912057212 hasConceptScore W2912057212C50254741 @default.
• W2912057212 hasConceptScore W2912057212C53345823 @default.
• W2912057212 hasConceptScore W2912057212C55493867 @default.
• W2912057212 hasConceptScore W2912057212C70721500 @default.

• next