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- W2912059416 endingPage "200" @default.
- W2912059416 startingPage "185" @default.
- W2912059416 abstract "Cancer changes the proteome in complex ways that reach well beyond simple changes in protein abundance. Genomic and transcriptional variations and post-translational protein modification create functional variants of a protein, known as proteoforms. Childhood cancers have fewer genomic alterations but show equally dramatic phenotypic changes as malignant cells in adults. Therefore, unraveling the complexities of the proteome is even more important in pediatric malignancies. Areas covered: In this review, the biological origins of proteoforms and technological advancements in the study of proteoforms are discussed. Particular emphasis is given to their implication in childhood malignancies and the critical role of cancer-specific proteoforms for the next generation of cancer therapies and diagnostics. Expert opinion: Recent advancements in technology have led to a better understanding of the underlying mechanisms of tumorigenesis. This has been critical for the development of more effective and less harmful treatments that are based on direct targeting of altered proteins and deregulated pathways. As proteome coverage and the ability to detect complex proteoforms increase, the most need for change is in data compilation and database availability to mediate high-level data analysis and allow for better functional annotation of proteoforms." @default.
- W2912059416 created "2019-02-21" @default.
- W2912059416 creator A5029643976 @default.
- W2912059416 creator A5075180335 @default.
- W2912059416 creator A5082879988 @default.
- W2912059416 date "2019-02-18" @default.
- W2912059416 modified "2023-10-13" @default.
- W2912059416 title "Origins and clinical relevance of proteoforms in pediatric malignancies" @default.
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