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- W2912060112 endingPage "3071" @default.
- W2912060112 startingPage "3058" @default.
- W2912060112 abstract "Proper repair of oxidatively damaged DNA bases is essential to maintain genome stability. 8-Oxoguanine (7,8-dihydro-8-oxoguanine, 8-oxoG) is a dangerous DNA lesion because it can mispair with adenine (A) during replication resulting in guanine to thymine transversion mutations. MUTYH DNA glycosylase is responsible for recognizing and removing the adenine from 8-oxoG:adenine (8-oxoG:A) sites. Biallelic mutations in the MUTYH gene predispose individuals to MUTYH-associated polyposis (MAP), and the most commonly observed mutation in some MAP populations is Y165C. Tyr165 is a 'wedge' residue that intercalates into the DNA duplex in the lesion bound state. Here, we utilize single molecule fluorescence microscopy to visualize the real-time search behavior of Escherichia coli and Mus musculus MUTYH WT and wedge variant orthologs on DNA tightropes that contain 8-oxoG:A, 8-oxoG:cytosine, or apurinic product analog sites. We observe that MUTYH WT is able to efficiently find 8-oxoG:A damage and form highly stable bound complexes. In contrast, MUTYH Y150C shows decreased binding lifetimes on undamaged DNA and fails to form a stable lesion recognition complex at damage sites. These findings suggest that MUTYH does not rely upon the wedge residue for damage site recognition, but this residue stabilizes the lesion recognition complex." @default.
- W2912060112 created "2019-02-21" @default.
- W2912060112 creator A5006547266 @default.
- W2912060112 creator A5007909721 @default.
- W2912060112 creator A5023718239 @default.
- W2912060112 creator A5024832019 @default.
- W2912060112 creator A5044576321 @default.
- W2912060112 creator A5069584048 @default.
- W2912060112 creator A5074504576 @default.
- W2912060112 date "2019-01-30" @default.
- W2912060112 modified "2023-09-25" @default.
- W2912060112 title "Single molecule glycosylase studies with engineered 8-oxoguanine DNA damage sites show functional defects of a MUTYH polyposis variant" @default.
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- W2912060112 doi "https://doi.org/10.1093/nar/gkz045" @default.
- W2912060112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6451117" @default.
- W2912060112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30698731" @default.
- W2912060112 hasPublicationYear "2019" @default.