FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912062350> ?p ?o ?g. }

• W2912062350 endingPage "1609" @default.
• W2912062350 startingPage "1599" @default.
• W2912062350 abstract "Bile salts, phospholipids, and digestive proteins are amphipathic compounds found naturally in the human gastrointestinal system. Therefore, it is important to consider their effects on the crystallization kinetics and solution behavior of drugs intended for oral delivery. Supersaturating drug delivery systems that employ high energy solid forms and polymeric additives are often hailed as the gold standard for increasing drug concentration in the gastrointestinal system. However, the effects of amphiphilic compounds present in the gastrointestinal system on the crystallization behavior of these systems are often overlooked. In this study, the effects of bile salts, phospholipids, mixtures of phospholipids and bile salts as well as digestive proteins on the crystallization kinetics of the antimicrobial agent clofazimine were evaluated. The crystallization inhibitory properties of these gastrointestinal amphiphiles were compared with commonly used synthetic polymers, and several of these amphipathic gastrointestinal compounds showed promise as crystallization inhibitors of clofazimine hydrochloride during induction time experiments. The best crystallization inhibitors from this induction time screening were then compared as solid physical mixtures in modified-fasted state simulated gastric fluid. Here it was found that heterogeneous nucleation of clofazimine hydrochloride occurred onto the dissolving surface of the administered clofazimine solid forms, preventing the various gastrointestinal compounds from inhibiting crystallization in this biorelevant media. This heterogeneous nucleation of clofazimine hydrochloride was monitored in real time, using optical microscopy techniques." @default.
• W2912062350 created "2019-02-21" @default.
• W2912062350 creator A5033970103 @default.
• W2912062350 creator A5064278171 @default.
• W2912062350 creator A5068058528 @default.
• W2912062350 date "2019-01-24" @default.
• W2912062350 modified "2023-09-28" @default.
• W2912062350 title "Overcoming the Common Ion Effect for Weakly Basic Drugs: Inhibiting the Crystallization of Clofazimine Hydrochloride in Simulated Gastrointestinal Media" @default.
• W2912062350 cites W1951885505 @default.
• W2912062350 cites W1969953227 @default.
• W2912062350 cites W1979787538 @default.
• W2912062350 cites W1981168366 @default.
• W2912062350 cites W1990663620 @default.
• W2912062350 cites W1993885178 @default.
• W2912062350 cites W2004468948 @default.
• W2912062350 cites W2019563422 @default.
• W2912062350 cites W2026049752 @default.
• W2912062350 cites W2028811150 @default.
• W2912062350 cites W2042824209 @default.
• W2912062350 cites W2062662048 @default.
• W2912062350 cites W2069506489 @default.
• W2912062350 cites W2082697065 @default.
• W2912062350 cites W2087739820 @default.
• W2912062350 cites W2087909593 @default.
• W2912062350 cites W2131719123 @default.
• W2912062350 cites W2133061394 @default.
• W2912062350 cites W2138252023 @default.
• W2912062350 cites W2225983686 @default.
• W2912062350 cites W2328474694 @default.
• W2912062350 cites W2335512730 @default.
• W2912062350 cites W2523598733 @default.
• W2912062350 cites W2537643667 @default.
• W2912062350 cites W2552432299 @default.
• W2912062350 cites W2552664055 @default.
• W2912062350 cites W2557877458 @default.
• W2912062350 cites W2566792724 @default.
• W2912062350 cites W2602815175 @default.
• W2912062350 cites W2613862808 @default.
• W2912062350 cites W2734545209 @default.
• W2912062350 cites W2737201932 @default.
• W2912062350 cites W2773638645 @default.
• W2912062350 cites W2890692657 @default.
• W2912062350 cites W2892432880 @default.
• W2912062350 cites W2952528349 @default.
• W2912062350 doi "https://doi.org/10.1021/acs.cgd.8b01365" @default.
• W2912062350 hasPublicationYear "2019" @default.
• W2912062350 type Work @default.
• W2912062350 sameAs 2912062350 @default.
• W2912062350 citedByCount "4" @default.
• W2912062350 countsByYear W29120623502020 @default.
• W2912062350 countsByYear W29120623502023 @default.
• W2912062350 crossrefType "journal-article" @default.
• W2912062350 hasAuthorship W2912062350A5033970103 @default.
• W2912062350 hasAuthorship W2912062350A5064278171 @default.
• W2912062350 hasAuthorship W2912062350A5068058528 @default.
• W2912062350 hasBestOaLocation W29120623502 @default.
• W2912062350 hasConcept C13245373 @default.
• W2912062350 hasConcept C155574463 @default.
• W2912062350 hasConcept C15920480 @default.
• W2912062350 hasConcept C16005928 @default.
• W2912062350 hasConcept C178790620 @default.
• W2912062350 hasConcept C185154212 @default.
• W2912062350 hasConcept C185592680 @default.
• W2912062350 hasConcept C203036418 @default.
• W2912062350 hasConcept C2776297342 @default.
• W2912062350 hasConcept C2776460385 @default.
• W2912062350 hasConcept C2779820397 @default.
• W2912062350 hasConcept C2780695269 @default.
• W2912062350 hasConcept C521977710 @default.
• W2912062350 hasConcept C55493867 @default.
• W2912062350 hasConcept C61048295 @default.
• W2912062350 hasConcept C67407626 @default.
• W2912062350 hasConcept C71924100 @default.
• W2912062350 hasConcept C88380143 @default.
• W2912062350 hasConceptScore W2912062350C13245373 @default.
• W2912062350 hasConceptScore W2912062350C155574463 @default.
• W2912062350 hasConceptScore W2912062350C15920480 @default.
• W2912062350 hasConceptScore W2912062350C16005928 @default.
• W2912062350 hasConceptScore W2912062350C178790620 @default.
• W2912062350 hasConceptScore W2912062350C185154212 @default.
• W2912062350 hasConceptScore W2912062350C185592680 @default.
• W2912062350 hasConceptScore W2912062350C203036418 @default.
• W2912062350 hasConceptScore W2912062350C2776297342 @default.
• W2912062350 hasConceptScore W2912062350C2776460385 @default.
• W2912062350 hasConceptScore W2912062350C2779820397 @default.
• W2912062350 hasConceptScore W2912062350C2780695269 @default.
• W2912062350 hasConceptScore W2912062350C521977710 @default.
• W2912062350 hasConceptScore W2912062350C55493867 @default.
• W2912062350 hasConceptScore W2912062350C61048295 @default.
• W2912062350 hasConceptScore W2912062350C67407626 @default.
• W2912062350 hasConceptScore W2912062350C71924100 @default.
• W2912062350 hasConceptScore W2912062350C88380143 @default.
• W2912062350 hasFunder F4320320838 @default.
• W2912062350 hasFunder F4320320847 @default.
• W2912062350 hasFunder F4320338080 @default.
• W2912062350 hasIssue "3" @default.
• W2912062350 hasLocation W29120623501 @default.
• W2912062350 hasLocation W29120623502 @default.

• next