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- W2912063221 abstract "Human aging is currently defined as a physiological decline of biological functions in the body with a continual adaptation to internal and external damaging. The endocrine system plays a major role in orchestrating cellular interactions, metabolism, growth, and aging. Several in vivo studies from worms to mice showed that downregulated activity of the GH/IGF-1/insulin pathway could be beneficial for the extension of human life span. While results are contradictory in humans. In the present review, we discussed the potential role of the IGF-1 system in the modulation of longevity, hypothesizing that the endocrine and metabolic adaptation observed in centenarians and in mammals during caloric restriction may be a physiological strategy for extending lifespan through a slower cell growing/metabolism, a better physiologic reserve capacity, a shift of cellular metabolism from cell proliferation to repair activities and a decrease in accumulation of senescent cells." @default.
- W2912063221 created "2019-02-21" @default.
- W2912063221 creator A5006066076 @default.
- W2912063221 creator A5009292091 @default.
- W2912063221 creator A5027452496 @default.
- W2912063221 creator A5054524217 @default.
- W2912063221 date "2019-02-01" @default.
- W2912063221 modified "2023-10-15" @default.
- W2912063221 title "ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians' Perspective" @default.
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