FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912063799> ?p ?o ?g. }

• W2912063799 endingPage "1343" @default.
• W2912063799 startingPage "1334" @default.
• W2912063799 abstract "The role of mitochondrial DNA (mt-DNA) changes, especially those in the regulatory D-loop region in Acute Myeloid Leukemia (AML) remains investigational. Consecutive 151 de novo pediatric AML patients, (≤18 yr) were prospectively enrolled from June 2013-August 2016, to assess the prognostic impact of mt-DNA D-loop variations (somatic/germline) on survival. For each patient, D-loop region was sequenced on baseline bone marrow and buccal swab, and mother's blood sample. In 151 AML subjects, 1490 variations were found at 237 positions; 80.9% were germline and 19.1% somatic. The mean number of variations per position was 6.3. Variations with frequency ≥6 were analyzed for their impact on survival and 4 categories were created, namely somatic-protective, somatic-hazardous, germline-protective and germline- hazardous. Although, somatic-protective could not predict event free survival (EFS) or overall survival (OS), somatic-hazardous [(OS) HR = 2.33, p = 0.06] and germline-hazardous [(OS) HR = 2.85, p < 0.01] significantly predicted OS and EFS. Notably, the germline-protective, could significantly predict EFS (HR = 0.31, p = 0.03) and OS (HR = 0.19, p < 0.01), only when variations at ≥2 positions were present. On multivariate analysis, three positions namely 16111, 16126, 16362 and karyotype were found to be predictive of EFS. A prognostic index (PI) was developed using nomogram PI = (0.8*karyotype) + (1.0*c16111) + (0.7*t16362) + (1.2*t16126). Hazard ratio for EFS increased significantly with increasing PI reaching to a maximum of 3.3 (p < 0.01). In conclusion, the impact of mt-DNA D-loop variations on outcomes in pediatric AML depends on their nature (germline/somatic), position and mutational burden, highlighting their potential role as evolving prognostic biomarkers." @default.
• W2912063799 created "2019-02-21" @default.
• W2912063799 creator A5000530935 @default.
• W2912063799 creator A5006047146 @default.
• W2912063799 creator A5018716048 @default.
• W2912063799 creator A5048060218 @default.
• W2912063799 creator A5070148724 @default.
• W2912063799 date "2019-02-12" @default.
• W2912063799 modified "2023-10-16" @default.
• W2912063799 title "Prognostic impact of mitochondrial DNA D-loop variations in pediatric acute myeloid leukemia" @default.
• W2912063799 cites W1802071044 @default.
• W2912063799 cites W1968591573 @default.
• W2912063799 cites W1979610420 @default.
• W2912063799 cites W1992360116 @default.
• W2912063799 cites W1993092131 @default.
• W2912063799 cites W1999164708 @default.
• W2912063799 cites W2013384669 @default.
• W2912063799 cites W2015240769 @default.
• W2912063799 cites W2022994848 @default.
• W2912063799 cites W2025086811 @default.
• W2912063799 cites W2025976421 @default.
• W2912063799 cites W2026327769 @default.
• W2912063799 cites W2060677651 @default.
• W2912063799 cites W2068819152 @default.
• W2912063799 cites W2074143890 @default.
• W2912063799 cites W2085869603 @default.
• W2912063799 cites W2109291482 @default.
• W2912063799 cites W2110784032 @default.
• W2912063799 cites W2114938052 @default.
• W2912063799 cites W2135365094 @default.
• W2912063799 cites W2156274776 @default.
• W2912063799 cites W2166740727 @default.
• W2912063799 cites W2326071176 @default.
• W2912063799 cites W2333704821 @default.
• W2912063799 cites W2531327700 @default.
• W2912063799 cites W2534833541 @default.
• W2912063799 cites W2559537906 @default.
• W2912063799 cites W2725930552 @default.
• W2912063799 cites W2756158662 @default.
• W2912063799 cites W2797675588 @default.
• W2912063799 cites W2804473310 @default.
• W2912063799 doi "https://doi.org/10.18632/oncotarget.26665" @default.
• W2912063799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6407682" @default.
• W2912063799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30863493" @default.
• W2912063799 hasPublicationYear "2019" @default.
• W2912063799 type Work @default.
• W2912063799 sameAs 2912063799 @default.
• W2912063799 citedByCount "6" @default.
• W2912063799 countsByYear W29120637992019 @default.
• W2912063799 countsByYear W29120637992021 @default.
• W2912063799 countsByYear W29120637992022 @default.
• W2912063799 countsByYear W29120637992023 @default.
• W2912063799 crossrefType "journal-article" @default.
• W2912063799 hasAuthorship W2912063799A5000530935 @default.
• W2912063799 hasAuthorship W2912063799A5006047146 @default.
• W2912063799 hasAuthorship W2912063799A5018716048 @default.
• W2912063799 hasAuthorship W2912063799A5048060218 @default.
• W2912063799 hasAuthorship W2912063799A5070148724 @default.
• W2912063799 hasBestOaLocation W29120637991 @default.
• W2912063799 hasConcept C104317684 @default.
• W2912063799 hasConcept C109825262 @default.
• W2912063799 hasConcept C126322002 @default.
• W2912063799 hasConcept C134305767 @default.
• W2912063799 hasConcept C13514818 @default.
• W2912063799 hasConcept C143998085 @default.
• W2912063799 hasConcept C167871757 @default.
• W2912063799 hasConcept C207103383 @default.
• W2912063799 hasConcept C2778729363 @default.
• W2912063799 hasConcept C34626388 @default.
• W2912063799 hasConcept C44249647 @default.
• W2912063799 hasConcept C501734568 @default.
• W2912063799 hasConcept C54355233 @default.
• W2912063799 hasConcept C71924100 @default.
• W2912063799 hasConcept C86803240 @default.
• W2912063799 hasConceptScore W2912063799C104317684 @default.
• W2912063799 hasConceptScore W2912063799C109825262 @default.
• W2912063799 hasConceptScore W2912063799C126322002 @default.
• W2912063799 hasConceptScore W2912063799C134305767 @default.
• W2912063799 hasConceptScore W2912063799C13514818 @default.
• W2912063799 hasConceptScore W2912063799C143998085 @default.
• W2912063799 hasConceptScore W2912063799C167871757 @default.
• W2912063799 hasConceptScore W2912063799C207103383 @default.
• W2912063799 hasConceptScore W2912063799C2778729363 @default.
• W2912063799 hasConceptScore W2912063799C34626388 @default.
• W2912063799 hasConceptScore W2912063799C44249647 @default.
• W2912063799 hasConceptScore W2912063799C501734568 @default.
• W2912063799 hasConceptScore W2912063799C54355233 @default.
• W2912063799 hasConceptScore W2912063799C71924100 @default.
• W2912063799 hasConceptScore W2912063799C86803240 @default.
• W2912063799 hasIssue "13" @default.
• W2912063799 hasLocation W29120637991 @default.
• W2912063799 hasLocation W29120637992 @default.
• W2912063799 hasLocation W29120637993 @default.
• W2912063799 hasLocation W29120637994 @default.
• W2912063799 hasOpenAccess W2912063799 @default.
• W2912063799 hasPrimaryLocation W29120637991 @default.
• W2912063799 hasRelatedWork W1575389553 @default.
• W2912063799 hasRelatedWork W1973124149 @default.

• next