FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912065069> ?p ?o ?g. }

• W2912065069 endingPage "44" @default.
• W2912065069 startingPage "44" @default.
• W2912065069 abstract "It has recently emerged that human chromosomes vary between one another in terms of features that impact their behaviour during impaired chromosome segregation, leading to non-random aneuploidy in the daughter cell population. During the process of chromosome congression to the metaphase plate, chromosome movement is guided by kinesin-like proteins, among which centromere-associated protein E (CENP-E) is important to transport chromosomes along the microtubules of the mitotic spindle. It is known that the inhibition of CENP-E notably impairs alignment for a subset of chromosomes, particularly those positioned close to the centrosome at nuclear envelope breakdown (‘polar chromosomes’); it is, however, not clear whether chromosome identity could influence this process. Since a popular strategy to model aneuploidy is to induce congression defects (for example combining CENP-E inhibitors with mitotic checkpoint abrogation), variance in congression efficiency between chromosomes might influence the landscape of aneuploidy and subsequent cell fates. By combining immunofluorescence, live cell imaging and fluorescence in situ hybridisation, we investigated the behaviour of polar chromosomes and their dependency upon CENP-E-mediated congression in human cells. We observed a bias in congression efficiency related to chromosome size, with larger chromosomes more sensitive to CENP-E inhibition. This bias is likely due to two contributing factors; an initial propensity of larger chromosomes to be peripheral and thus rely more upon CENP-E function to migrate to the metaphase plate, and additionally a bias between specific chromosomes’ ability to congress from a polar state. These findings may help to explain the persistence of a subset of chromosomes at the centrosome following CENP-E disruption, and also have implications for the spectrum of aneuploidy generated following treatments to manipulate CENP-E function." @default.
• W2912065069 created "2019-02-21" @default.
• W2912065069 creator A5040708479 @default.
• W2912065069 creator A5041589194 @default.
• W2912065069 date "2019-01-26" @default.
• W2912065069 modified "2023-10-01" @default.
• W2912065069 title "Impaired CENP-E Function Renders Large Chromosomes More Vulnerable to Congression Failure" @default.
• W2912065069 cites W1971165751 @default.
• W2912065069 cites W1972007367 @default.
• W2912065069 cites W198614898 @default.
• W2912065069 cites W1988963409 @default.
• W2912065069 cites W1995850464 @default.
• W2912065069 cites W2047828925 @default.
• W2912065069 cites W2054929208 @default.
• W2912065069 cites W2056520842 @default.
• W2912065069 cites W2058703970 @default.
• W2912065069 cites W2063766478 @default.
• W2912065069 cites W2064009910 @default.
• W2912065069 cites W2089777409 @default.
• W2912065069 cites W2090578629 @default.
• W2912065069 cites W2092499706 @default.
• W2912065069 cites W2102922697 @default.
• W2912065069 cites W2110382902 @default.
• W2912065069 cites W2116376484 @default.
• W2912065069 cites W2118612987 @default.
• W2912065069 cites W2140493627 @default.
• W2912065069 cites W2151805953 @default.
• W2912065069 cites W2399814379 @default.
• W2912065069 cites W2475124410 @default.
• W2912065069 cites W2553250671 @default.
• W2912065069 cites W2588416196 @default.
• W2912065069 cites W2691929059 @default.
• W2912065069 cites W2792238040 @default.
• W2912065069 cites W2794258426 @default.
• W2912065069 cites W2795441313 @default.
• W2912065069 cites W2896800728 @default.
• W2912065069 cites W4211071958 @default.
• W2912065069 doi "https://doi.org/10.3390/biom9020044" @default.
• W2912065069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6406671" @default.
• W2912065069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30691136" @default.
• W2912065069 hasPublicationYear "2019" @default.
• W2912065069 type Work @default.
• W2912065069 sameAs 2912065069 @default.
• W2912065069 citedByCount "17" @default.
• W2912065069 countsByYear W29120650692019 @default.
• W2912065069 countsByYear W29120650692020 @default.
• W2912065069 countsByYear W29120650692021 @default.
• W2912065069 countsByYear W29120650692022 @default.
• W2912065069 countsByYear W29120650692023 @default.
• W2912065069 crossrefType "journal-article" @default.
• W2912065069 hasAuthorship W2912065069A5040708479 @default.
• W2912065069 hasAuthorship W2912065069A5041589194 @default.
• W2912065069 hasBestOaLocation W29120650691 @default.
• W2912065069 hasConcept C104317684 @default.
• W2912065069 hasConcept C2778354886 @default.
• W2912065069 hasConcept C2779672484 @default.
• W2912065069 hasConcept C2908647359 @default.
• W2912065069 hasConcept C30481170 @default.
• W2912065069 hasConcept C54355233 @default.
• W2912065069 hasConcept C63491729 @default.
• W2912065069 hasConcept C70278784 @default.
• W2912065069 hasConcept C71924100 @default.
• W2912065069 hasConcept C86803240 @default.
• W2912065069 hasConcept C93304396 @default.
• W2912065069 hasConcept C95444343 @default.
• W2912065069 hasConcept C99454951 @default.
• W2912065069 hasConceptScore W2912065069C104317684 @default.
• W2912065069 hasConceptScore W2912065069C2778354886 @default.
• W2912065069 hasConceptScore W2912065069C2779672484 @default.
• W2912065069 hasConceptScore W2912065069C2908647359 @default.
• W2912065069 hasConceptScore W2912065069C30481170 @default.
• W2912065069 hasConceptScore W2912065069C54355233 @default.
• W2912065069 hasConceptScore W2912065069C63491729 @default.
• W2912065069 hasConceptScore W2912065069C70278784 @default.
• W2912065069 hasConceptScore W2912065069C71924100 @default.
• W2912065069 hasConceptScore W2912065069C86803240 @default.
• W2912065069 hasConceptScore W2912065069C93304396 @default.
• W2912065069 hasConceptScore W2912065069C95444343 @default.
• W2912065069 hasConceptScore W2912065069C99454951 @default.
• W2912065069 hasIssue "2" @default.
• W2912065069 hasLocation W29120650691 @default.
• W2912065069 hasLocation W29120650692 @default.
• W2912065069 hasLocation W29120650693 @default.
• W2912065069 hasLocation W29120650694 @default.
• W2912065069 hasLocation W29120650695 @default.
• W2912065069 hasOpenAccess W2912065069 @default.
• W2912065069 hasPrimaryLocation W29120650691 @default.
• W2912065069 hasRelatedWork W18298229 @default.
• W2912065069 hasRelatedWork W2002875814 @default.
• W2912065069 hasRelatedWork W2011054691 @default.
• W2912065069 hasRelatedWork W2043401889 @default.
• W2912065069 hasRelatedWork W2075313629 @default.
• W2912065069 hasRelatedWork W2085711044 @default.
• W2912065069 hasRelatedWork W2618369267 @default.
• W2912065069 hasRelatedWork W2885624243 @default.
• W2912065069 hasRelatedWork W4294916280 @default.
• W2912065069 hasRelatedWork W2049012161 @default.
• W2912065069 hasVolume "9" @default.

• next