FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912073938> ?p ?o ?g. }

• W2912073938 endingPage "69" @default.
• W2912073938 startingPage "58" @default.
• W2912073938 abstract "Immunotherapy might be an effective treatment in extrahepatic cholangiocarcinoma (eCCA), a tumor with extremely limited therapeutic options. Our study is to characterize the programmed death ligand-1 (PD-L1) protein expression and cancer microenvironment profiles in surgically resected eCCA samples. PD-L1 positivity was observed on tumor cells (32.3%) as well as on tumor-associated macrophages (74.2%). PD-L1 expression by eCCA correlated significantly with immune parameters such as intra-tumoral CD3+ tumor infiltrating lymphocytes (TILs) density (P = 0.002), intra-tumoral CD8+ TILs density (P < 0.001), and the expression pattern of human leukocyte antigen (HLA) class I (P < 0.001). Immunofluorescence showed that PD-L1 positive tumor cells were adjacent to PD-1 positive cells and the stroma covered with interferon-γ. Correlation with clinicopathological parameters and survival analyses revealed that PD-L1 positivity in eCCA was related to the absence of venous invasion (P = 0.030), improved overall survival (P = 0.020) and progressionfree survival (P = 0.011). HLA class I molecules defect, which is an important mechanism of immune evasion, was frequently observed in eCCA (50.0%) and was associated with a decreased number of intra-tumoral CD8+ TIL density (P = 0.028). Additionally, the presence of unusually high numbers of tumor-associated macrophages (TAMs) subsets M2 in most of eCCA (74.2%) was noted. Our study indicated that PD-L1 expression in association with intra-tumoral TILs infiltration and HLA class I expression in 32.3% of the eCCA reflects an active immune microenvironment potentially responsive to PD-1/PD-L1 inhibitors. In addition, the combination of macrophage-targeting agents may provide therapeutic synergy for future immunotherapy." @default.
• W2912073938 created "2019-02-21" @default.
• W2912073938 creator A5015941282 @default.
• W2912073938 creator A5021104669 @default.
• W2912073938 creator A5027475930 @default.
• W2912073938 creator A5028514549 @default.
• W2912073938 creator A5044339430 @default.
• W2912073938 creator A5059242151 @default.
• W2912073938 creator A5083314108 @default.
• W2912073938 creator A5083998269 @default.
• W2912073938 creator A5085240549 @default.
• W2912073938 creator A5085782487 @default.
• W2912073938 date "2019-02-28" @default.
• W2912073938 modified "2023-10-14" @default.
• W2912073938 title "Programmed death ligand-1, tumor infiltrating lymphocytes and HLA expression in Chinese extrahepatic cholangiocarcinoma patients: Possible immunotherapy implications" @default.
• W2912073938 cites W1971620413 @default.
• W2912073938 cites W1975992327 @default.
• W2912073938 cites W1997362383 @default.
• W2912073938 cites W2002097423 @default.
• W2912073938 cites W2006908114 @default.
• W2912073938 cites W2007555374 @default.
• W2912073938 cites W2008389446 @default.
• W2912073938 cites W2009392040 @default.
• W2912073938 cites W2016732129 @default.
• W2912073938 cites W2034770797 @default.
• W2912073938 cites W2058648826 @default.
• W2912073938 cites W2061318890 @default.
• W2912073938 cites W2063104485 @default.
• W2912073938 cites W2069592230 @default.
• W2912073938 cites W2077852908 @default.
• W2912073938 cites W2088538447 @default.
• W2912073938 cites W2102310375 @default.
• W2912073938 cites W2122339079 @default.
• W2912073938 cites W2124631712 @default.
• W2912073938 cites W2135885240 @default.
• W2912073938 cites W2140875987 @default.
• W2912073938 cites W2141078344 @default.
• W2912073938 cites W2143772132 @default.
• W2912073938 cites W2158186400 @default.
• W2912073938 cites W2159999569 @default.
• W2912073938 cites W2185251512 @default.
• W2912073938 cites W2269620328 @default.
• W2912073938 cites W2488061344 @default.
• W2912073938 cites W2531714941 @default.
• W2912073938 cites W2555713829 @default.
• W2912073938 cites W2560305660 @default.
• W2912073938 cites W2564105093 @default.
• W2912073938 cites W2569537049 @default.
• W2912073938 cites W2583745495 @default.
• W2912073938 cites W2593977463 @default.
• W2912073938 cites W2607173021 @default.
• W2912073938 cites W2609802199 @default.
• W2912073938 cites W2660993003 @default.
• W2912073938 cites W2724543993 @default.
• W2912073938 cites W2752475919 @default.
• W2912073938 cites W2753114438 @default.
• W2912073938 cites W2762910263 @default.
• W2912073938 cites W2766287142 @default.
• W2912073938 cites W2767395146 @default.
• W2912073938 cites W2793908502 @default.
• W2912073938 cites W2796789662 @default.
• W2912073938 cites W2898222983 @default.
• W2912073938 cites W4211025847 @default.
• W2912073938 cites W951317561 @default.
• W2912073938 doi "https://doi.org/10.5582/bst.2019.01003" @default.
• W2912073938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30773525" @default.
• W2912073938 hasPublicationYear "2019" @default.
• W2912073938 type Work @default.
• W2912073938 sameAs 2912073938 @default.
• W2912073938 citedByCount "16" @default.
• W2912073938 countsByYear W29120739382019 @default.
• W2912073938 countsByYear W29120739382020 @default.
• W2912073938 countsByYear W29120739382021 @default.
• W2912073938 countsByYear W29120739382022 @default.
• W2912073938 countsByYear W29120739382023 @default.
• W2912073938 crossrefType "journal-article" @default.
• W2912073938 hasAuthorship W2912073938A5015941282 @default.
• W2912073938 hasAuthorship W2912073938A5021104669 @default.
• W2912073938 hasAuthorship W2912073938A5027475930 @default.
• W2912073938 hasAuthorship W2912073938A5028514549 @default.
• W2912073938 hasAuthorship W2912073938A5044339430 @default.
• W2912073938 hasAuthorship W2912073938A5059242151 @default.
• W2912073938 hasAuthorship W2912073938A5083314108 @default.
• W2912073938 hasAuthorship W2912073938A5083998269 @default.
• W2912073938 hasAuthorship W2912073938A5085240549 @default.
• W2912073938 hasAuthorship W2912073938A5085782487 @default.
• W2912073938 hasBestOaLocation W29120739381 @default.
• W2912073938 hasConcept C147483822 @default.
• W2912073938 hasConcept C167672396 @default.
• W2912073938 hasConcept C188280979 @default.
• W2912073938 hasConcept C203014093 @default.
• W2912073938 hasConcept C204232928 @default.
• W2912073938 hasConcept C2776107976 @default.
• W2912073938 hasConcept C2776885095 @default.
• W2912073938 hasConcept C2777701055 @default.
• W2912073938 hasConcept C2778326572 @default.
• W2912073938 hasConcept C2781053074 @default.
• W2912073938 hasConcept C502942594 @default.

• next