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- W2912074053 abstract "Cortical excitability depends on sleep-wake regulation, is central to cognition, and has been implicated in age-related cognitive decline. The dynamics of cortical excitability during prolonged wakefulness in aging are unknown, however. Here, we repeatedly probed cortical excitability of the frontal cortex using transcranial magnetic stimulation and electroencephalography in 13 young and 12 older healthy participants during sleep deprivation. Although overall cortical excitability did not differ between age groups, the magnitude of cortical excitability variations during prolonged wakefulness was dampened in older individuals. This age-related dampening was associated with mitigated neurobehavioral consequences of sleep loss on executive functions. Furthermore, higher cortical excitability was potentially associated with better and lower executive performance, respectively, in older and younger adults. The dampening of cortical excitability dynamics found in older participants likely arises from a reduced impact of sleep homeostasis and circadian processes. It may reflect reduced brain adaptability underlying reduced cognitive flexibility in aging. Future research should confirm preliminary associations between cortical excitability and behavior and address whether maintaining cortical excitability dynamics can counteract age-related cognitive decline." @default.
- W2912074053 created "2019-02-21" @default.
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- W2912074053 date "2019-06-01" @default.
- W2912074053 modified "2023-09-27" @default.
- W2912074053 title "Age-related decrease in cortical excitability circadian variations during sleep loss and its links with cognition" @default.
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- W2912074053 doi "https://doi.org/10.1016/j.neurobiolaging.2019.02.004" @default.
- W2912074053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30877839" @default.
- W2912074053 hasPublicationYear "2019" @default.
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