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- W2912075068 abstract "Under normal circumstances, the heart's rate and force of contraction is tightly regulated to meet the circulatory demands of the body. The sympathetic and parasympathetic nervous systems are primary regulators of cardiac output but a number of integrated systems of the body including the renal system, adrenal glands, vascular endothelium, immune system, and cardiac tissue itself play important roles in regulating circulation and hydroelectrolytic homeostasis. This chapter describes the cellular and molecular basis of myocardial excitation–contraction coupling, explains how the autonomic nervous system regulates excitation–contraction coupling, and examines emerging information on the mechanisms of arrhythmias and the new pharmacologic approaches being taken to treat arrhythmias and chronic heart failure. Much of the organizational structure and some informational content of the first edition of this chapter, written by Sheu and Colecraft (1997), has been retained; however, significant revisions and additions have been made to include dramatic advancements in understanding the molecular biology of ion channels, the autonomic receptor signaling pathways, and the genetic basis of some forms of arrhythmias." @default.
- W2912075068 created "2019-02-21" @default.
- W2912075068 creator A5039584185 @default.
- W2912075068 date "2018-01-01" @default.
- W2912075068 modified "2023-09-25" @default.
- W2912075068 title "Cardiac Physiology and Pharmacology" @default.
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- W2912075068 doi "https://doi.org/10.1016/b978-0-08-100601-6.00704-3" @default.
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