FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912076408> ?p ?o ?g. }

• W2912076408 abstract "Abstract Drebrin (DBN) regulates cytoskeletal functions during neuronal development, and is thought to contribute to structural and functional synaptic changes associated with aging and Alzheimer’s disease. Here we show that DBN coordinates stress signalling with cytoskeletal dynamics, via a mechanism involving kinase ataxia-telangiectasia mutated (ATM). An excess of reactive oxygen species (ROS) stimulates ATM-dependent phosphorylation of DBN at serine-647, which enhances protein stability and accounts for improved stress resilience in dendritic spines. We generated a humanized DBN Caenorhabditis elegans model and show that a phospho-DBN mutant disrupts the protective ATM effect on lifespan under sustained oxidative stress. Our data indicate a master regulatory function of ATM-DBN in integrating cytosolic stress-induced signalling with the dynamics of actin remodelling to provide protection from synapse dysfunction and ROS-triggered reduced lifespan. They further suggest that DBN protein abundance governs actin filament stability to contribute to the consequences of oxidative stress in physiological and pathological conditions." @default.
• W2912076408 created "2019-02-21" @default.
• W2912076408 creator A5015863270 @default.
• W2912076408 creator A5021633876 @default.
• W2912076408 creator A5040559525 @default.
• W2912076408 creator A5046148125 @default.
• W2912076408 creator A5056675508 @default.
• W2912076408 creator A5059374555 @default.
• W2912076408 creator A5061245461 @default.
• W2912076408 creator A5068269987 @default.
• W2912076408 creator A5085987925 @default.
• W2912076408 creator A5089435589 @default.
• W2912076408 creator A5089740203 @default.
• W2912076408 creator A5091465411 @default.
• W2912076408 date "2019-01-30" @default.
• W2912076408 modified "2023-10-01" @default.
• W2912076408 title "ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans" @default.
• W2912076408 cites W1850305390 @default.
• W2912076408 cites W1970965314 @default.
• W2912076408 cites W1973514051 @default.
• W2912076408 cites W1986219537 @default.
• W2912076408 cites W1987710873 @default.
• W2912076408 cites W1996892694 @default.
• W2912076408 cites W2001838314 @default.
• W2912076408 cites W2010643291 @default.
• W2912076408 cites W2015588918 @default.
• W2912076408 cites W2025018124 @default.
• W2912076408 cites W2026819189 @default.
• W2912076408 cites W2036671631 @default.
• W2912076408 cites W2039706181 @default.
• W2912076408 cites W2043475021 @default.
• W2912076408 cites W2046589688 @default.
• W2912076408 cites W2061893558 @default.
• W2912076408 cites W2066848236 @default.
• W2912076408 cites W2067132969 @default.
• W2912076408 cites W2068427957 @default.
• W2912076408 cites W2069271483 @default.
• W2912076408 cites W2074615071 @default.
• W2912076408 cites W2082429191 @default.
• W2912076408 cites W2082856520 @default.
• W2912076408 cites W2083541735 @default.
• W2912076408 cites W2084666187 @default.
• W2912076408 cites W2085525271 @default.
• W2912076408 cites W2090512499 @default.
• W2912076408 cites W2097335530 @default.
• W2912076408 cites W2099228538 @default.
• W2912076408 cites W2101988823 @default.
• W2912076408 cites W2124015317 @default.
• W2912076408 cites W2132612903 @default.
• W2912076408 cites W2141471665 @default.
• W2912076408 cites W2142186280 @default.
• W2912076408 cites W2149999139 @default.
• W2912076408 cites W2168334242 @default.
• W2912076408 cites W2289872273 @default.
• W2912076408 cites W2572273292 @default.
• W2912076408 cites W2774657197 @default.
• W2912076408 cites W2793768313 @default.
• W2912076408 cites W787732339 @default.
• W2912076408 doi "https://doi.org/10.1038/s41467-019-08420-w" @default.
• W2912076408 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6353951" @default.
• W2912076408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30700723" @default.
• W2912076408 hasPublicationYear "2019" @default.
• W2912076408 type Work @default.
• W2912076408 sameAs 2912076408 @default.
• W2912076408 citedByCount "23" @default.
• W2912076408 countsByYear W29120764082019 @default.
• W2912076408 countsByYear W29120764082020 @default.
• W2912076408 countsByYear W29120764082021 @default.
• W2912076408 countsByYear W29120764082022 @default.
• W2912076408 countsByYear W29120764082023 @default.
• W2912076408 crossrefType "journal-article" @default.
• W2912076408 hasAuthorship W2912076408A5015863270 @default.
• W2912076408 hasAuthorship W2912076408A5021633876 @default.
• W2912076408 hasAuthorship W2912076408A5040559525 @default.
• W2912076408 hasAuthorship W2912076408A5046148125 @default.
• W2912076408 hasAuthorship W2912076408A5056675508 @default.
• W2912076408 hasAuthorship W2912076408A5059374555 @default.
• W2912076408 hasAuthorship W2912076408A5061245461 @default.
• W2912076408 hasAuthorship W2912076408A5068269987 @default.
• W2912076408 hasAuthorship W2912076408A5085987925 @default.
• W2912076408 hasAuthorship W2912076408A5089435589 @default.
• W2912076408 hasAuthorship W2912076408A5089740203 @default.
• W2912076408 hasAuthorship W2912076408A5091465411 @default.
• W2912076408 hasBestOaLocation W29120764081 @default.
• W2912076408 hasConcept C104317684 @default.
• W2912076408 hasConcept C11960822 @default.
• W2912076408 hasConcept C125705527 @default.
• W2912076408 hasConcept C127445978 @default.
• W2912076408 hasConcept C142669718 @default.
• W2912076408 hasConcept C148762608 @default.
• W2912076408 hasConcept C1491633281 @default.
• W2912076408 hasConcept C169760540 @default.
• W2912076408 hasConcept C174884520 @default.
• W2912076408 hasConcept C181199279 @default.
• W2912076408 hasConcept C185592680 @default.
• W2912076408 hasConcept C2776151105 @default.
• W2912076408 hasConcept C2778944004 @default.
• W2912076408 hasConcept C2993400109 @default.
• W2912076408 hasConcept C55493867 @default.
• W2912076408 hasConcept C86803240 @default.

• next