Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912076521> ?p ?o ?g. }
- W2912076521 abstract "A low oxygen supply to the fetus causes intrauterine growth restriction and can affect gonadal development of the offspring, having a potential impact on fertility. We investigated histology and gene expression in the postnatal rat ovary after fetal hypoxia induced by uterine artery ligation.Sprague-Dawley rats underwent uterine artery ligation at day 19 of gestation. Offspring were sacrificed at 5, 20 and 40 days post-partum. Follicles were counted and classified in hematoxylin-eosin stained sections. Gene expression of 90 genes was analyzed by TaqMan® Low Density Array.A significantly lower number of total and primordial follicles was detected in 20 days post-partum intrauterine growth restricted animals. Follicle density was not different at 40 days post-partum, suggesting that compensatory mechanisms occurred during the pre-pubertal window. Uterine artery ligation modified the expression of 24 genes involved in different cellular functions, among which proliferation, apoptosis and metabolism.Ovarian follicle pool was affected by fetal hypoxia in early life, but this effect did not persist in puberty. Genes involved in cellular processes were affected at all ages, potentially implying long-term genetic alterations. Further analyses are needed to elucidate later effects of fetal hypoxia on ovarian function and fertility." @default.
- W2912076521 created "2019-02-21" @default.
- W2912076521 creator A5021660657 @default.
- W2912076521 creator A5046023727 @default.
- W2912076521 creator A5047799534 @default.
- W2912076521 creator A5074798655 @default.
- W2912076521 creator A5076309463 @default.
- W2912076521 creator A5083484856 @default.
- W2912076521 creator A5091083841 @default.
- W2912076521 date "2019-01-10" @default.
- W2912076521 modified "2023-10-12" @default.
- W2912076521 title "Impact of uteroplacental insufficiency on ovarian follicular pool in the rat" @default.
- W2912076521 cites W143741960 @default.
- W2912076521 cites W1903344188 @default.
- W2912076521 cites W1968802003 @default.
- W2912076521 cites W1978799899 @default.
- W2912076521 cites W1980399043 @default.
- W2912076521 cites W1982575480 @default.
- W2912076521 cites W1986704518 @default.
- W2912076521 cites W1996613476 @default.
- W2912076521 cites W1996806784 @default.
- W2912076521 cites W2014246283 @default.
- W2912076521 cites W2015455880 @default.
- W2912076521 cites W2015925133 @default.
- W2912076521 cites W2020445250 @default.
- W2912076521 cites W2026175834 @default.
- W2912076521 cites W2032355582 @default.
- W2912076521 cites W2035653331 @default.
- W2912076521 cites W2047247552 @default.
- W2912076521 cites W2057964989 @default.
- W2912076521 cites W2061451259 @default.
- W2912076521 cites W2074467897 @default.
- W2912076521 cites W2080700340 @default.
- W2912076521 cites W2090489384 @default.
- W2912076521 cites W2093559962 @default.
- W2912076521 cites W2099724528 @default.
- W2912076521 cites W2106731493 @default.
- W2912076521 cites W2107500974 @default.
- W2912076521 cites W2113154513 @default.
- W2912076521 cites W2117706615 @default.
- W2912076521 cites W2117882094 @default.
- W2912076521 cites W2120987058 @default.
- W2912076521 cites W2136159364 @default.
- W2912076521 cites W2139965289 @default.
- W2912076521 cites W2142272530 @default.
- W2912076521 cites W2147229982 @default.
- W2912076521 cites W2159541354 @default.
- W2912076521 cites W2161545045 @default.
- W2912076521 cites W2162298564 @default.
- W2912076521 cites W2162306659 @default.
- W2912076521 cites W2166229423 @default.
- W2912076521 cites W2170550739 @default.
- W2912076521 cites W2219578023 @default.
- W2912076521 cites W2259780124 @default.
- W2912076521 cites W2398396901 @default.
- W2912076521 cites W2551588929 @default.
- W2912076521 cites W2604872644 @default.
- W2912076521 cites W2610861154 @default.
- W2912076521 cites W3046226531 @default.
- W2912076521 doi "https://doi.org/10.1186/s12958-019-0453-3" @default.
- W2912076521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6329190" @default.
- W2912076521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30630482" @default.
- W2912076521 hasPublicationYear "2019" @default.
- W2912076521 type Work @default.
- W2912076521 sameAs 2912076521 @default.
- W2912076521 citedByCount "7" @default.
- W2912076521 countsByYear W29120765212020 @default.
- W2912076521 countsByYear W29120765212021 @default.
- W2912076521 countsByYear W29120765212022 @default.
- W2912076521 crossrefType "journal-article" @default.
- W2912076521 hasAuthorship W2912076521A5021660657 @default.
- W2912076521 hasAuthorship W2912076521A5046023727 @default.
- W2912076521 hasAuthorship W2912076521A5047799534 @default.
- W2912076521 hasAuthorship W2912076521A5074798655 @default.
- W2912076521 hasAuthorship W2912076521A5076309463 @default.
- W2912076521 hasAuthorship W2912076521A5083484856 @default.
- W2912076521 hasAuthorship W2912076521A5091083841 @default.
- W2912076521 hasBestOaLocation W29120765211 @default.
- W2912076521 hasConcept C112672928 @default.
- W2912076521 hasConcept C126322002 @default.
- W2912076521 hasConcept C134018914 @default.
- W2912076521 hasConcept C16685009 @default.
- W2912076521 hasConcept C172680121 @default.
- W2912076521 hasConcept C179437574 @default.
- W2912076521 hasConcept C187785154 @default.
- W2912076521 hasConcept C2778324911 @default.
- W2912076521 hasConcept C2778780700 @default.
- W2912076521 hasConcept C2779234561 @default.
- W2912076521 hasConcept C2781207646 @default.
- W2912076521 hasConcept C46973012 @default.
- W2912076521 hasConcept C54355233 @default.
- W2912076521 hasConcept C71924100 @default.
- W2912076521 hasConcept C86803240 @default.
- W2912076521 hasConceptScore W2912076521C112672928 @default.
- W2912076521 hasConceptScore W2912076521C126322002 @default.
- W2912076521 hasConceptScore W2912076521C134018914 @default.
- W2912076521 hasConceptScore W2912076521C16685009 @default.
- W2912076521 hasConceptScore W2912076521C172680121 @default.
- W2912076521 hasConceptScore W2912076521C179437574 @default.
- W2912076521 hasConceptScore W2912076521C187785154 @default.