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- W2912076569 abstract "Background AHCT with high dose melphalan (MEL200, 200 mg/m2) is considered a standard regimen for myeloma. We performed a retrospective analysis of the outcomes in patients who received our dose-intense regimen of carmustine (BCNU, 300-550 mg/m2) plus MEL200 in the era of proteosome inhibitors (PI) +/- IMiDs induction. Methods Three cohorts of patients were included for analysis: Cohort A (n=339) included patients who received BCNU/MEL200 followed by AHCT before 07/2006, representing a population before the PI +/- IMiDs era. Cohort B (n=465) and Cohort C (n=95) included patients from 01/2009 to 12/2016, representing populations in the PI +/- IMiDs era, who received BCNU/MEL200 or only MEL200, respectively. Primary endpoint was progression free survival (PFS) defined as time to disease progression or death from any cause after transplant. The PFS was analyzed using Kaplan-Meier estimation and log-rank test was used to test differences between groups. Results First, we compared patients between two different era who had BCNU/MEL200 regimen. As expected, Cohort B had a significantly longer PFS than Cohort A (median PFS: 3.28 vs 2.44 Yrs, p Conclusions Our dose-intense BCNU/MEL200 regimen was effective in this large patient cohort, and compared favorably to MEL200 especially in patients with suboptimal response (PR/SD) prior to transplant in the era of PI +/- IMIDs induction. A prospective randomized clinical trial comparing BCNU/MEL200 vs MEL200 is required to validate these findings which is being planned." @default.
- W2912076569 created "2019-02-21" @default.
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- W2912076569 date "2019-03-01" @default.
- W2912076569 modified "2023-09-27" @default.
- W2912076569 title "Dose-Intense BCNU/Melphalan Regimen Followed By Autologous Hematopoietic Cell Transplantation (AHCT) Results in Prolonged PFS in Myeloma Patients" @default.
- W2912076569 doi "https://doi.org/10.1016/j.bbmt.2018.12.808" @default.
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