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• W2912076589 abstract "The mechanisms responsible for the persistence of chemotherapy-induced peripheral neuropathy (CIPN) in a significant proportion of cancer survivors are still unknown. Our previous findings show that CD8 T cells are necessary for the resolution of paclitaxel-induced mechanical allodynia in male mice. In this study, we demonstrate that CD8 T cells are not only essential for resolving cisplatin-induced mechanical allodynia, but also to normalize spontaneous pain, numbness, and the reduction in intraepidermal nerve fiber density in male and female mice. Resolution of CIPN was not observed in Rag2 mice that lack T and B cells. Reconstitution of Rag2 mice with CD8 T cells before cisplatin treatment normalized the resolution of CIPN. In vivo education of CD8 T cells by cisplatin was necessary to induce resolution of CIPN in Rag2 mice because adoptive transfer of CD8 T cells from naive wild-type mice to Rag2 mice after completion of chemotherapy did not promote resolution of established CIPN. The CD8 T-cell-dependent resolution of CIPN does not require epitope recognition by the T-cell receptor. Moreover, adoptive transfer of cisplatin-educated CD8 T cells to Rag2 mice prevented CIPN development induced by either cisplatin or paclitaxel, indicating that the activity of the educated CD8 T is not cisplatin specific. In conclusion, resolution of CIPN requires in vivo education of CD8 T cells by exposure to cisplatin. Future studies should examine whether ex vivo CD8 T cell education could be applied as a therapeutic strategy for treating or preventing CIPN in patients." @default.
• W2912076589 created "2019-02-21" @default.
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• W2912076589 creator A5080230933 @default.
• W2912076589 creator A5080420947 @default.
• W2912076589 date "2019-01-31" @default.
• W2912076589 modified "2023-10-14" @default.
• W2912076589 title "Cisplatin educates CD8+ T cells to prevent and resolve chemotherapy-induced peripheral neuropathy in mice" @default.
• W2912076589 cites W1511837220 @default.
• W2912076589 cites W1560013893 @default.
• W2912076589 cites W1959677146 @default.
• W2912076589 cites W1966432380 @default.
• W2912076589 cites W1970202520 @default.
• W2912076589 cites W1974049018 @default.
• W2912076589 cites W1974424684 @default.
• W2912076589 cites W1977663897 @default.
• W2912076589 cites W1991929293 @default.
• W2912076589 cites W1994553016 @default.
• W2912076589 cites W1995300665 @default.
• W2912076589 cites W1996571434 @default.
• W2912076589 cites W1998185442 @default.
• W2912076589 cites W2001699192 @default.
• W2912076589 cites W2005018866 @default.
• W2912076589 cites W2009429694 @default.
• W2912076589 cites W2011033166 @default.
• W2912076589 cites W2014313724 @default.
• W2912076589 cites W2022745333 @default.
• W2912076589 cites W2027022038 @default.
• W2912076589 cites W2030276408 @default.
• W2912076589 cites W2033963984 @default.
• W2912076589 cites W2036709667 @default.
• W2912076589 cites W2052317102 @default.
• W2912076589 cites W2053242178 @default.
• W2912076589 cites W2056487354 @default.
• W2912076589 cites W2059190124 @default.
• W2912076589 cites W2062359151 @default.
• W2912076589 cites W2067087807 @default.
• W2912076589 cites W2077885131 @default.
• W2912076589 cites W2078844752 @default.
• W2912076589 cites W2081447688 @default.
• W2912076589 cites W2083433844 @default.
• W2912076589 cites W2087838893 @default.
• W2912076589 cites W2092211307 @default.
• W2912076589 cites W2107679943 @default.
• W2912076589 cites W2113345769 @default.
• W2912076589 cites W2114458368 @default.
• W2912076589 cites W2120177140 @default.
• W2912076589 cites W2132495467 @default.
• W2912076589 cites W2157282220 @default.
• W2912076589 cites W2168941432 @default.
• W2912076589 cites W2170259378 @default.
• W2912076589 cites W2172201406 @default.
• W2912076589 cites W2194931157 @default.
• W2912076589 cites W2196308323 @default.
• W2912076589 cites W2294088168 @default.
• W2912076589 cites W2294094636 @default.
• W2912076589 cites W2315122082 @default.
• W2912076589 cites W2321697502 @default.
• W2912076589 cites W2369050436 @default.
• W2912076589 cites W2469685265 @default.
• W2912076589 cites W2508975698 @default.
• W2912076589 cites W2514572740 @default.
• W2912076589 cites W2541434109 @default.
• W2912076589 cites W2547814918 @default.
• W2912076589 cites W2580584788 @default.
• W2912076589 cites W2586172468 @default.
• W2912076589 cites W2593043086 @default.
• W2912076589 cites W2613641182 @default.
• W2912076589 cites W2618045650 @default.
• W2912076589 cites W2736208466 @default.
• W2912076589 cites W2751735237 @default.
• W2912076589 cites W2766754072 @default.
• W2912076589 cites W2790265924 @default.
• W2912076589 cites W2791843796 @default.
• W2912076589 cites W2800936087 @default.
• W2912076589 cites W2808882111 @default.
• W2912076589 cites W2808959710 @default.
• W2912076589 cites W2884081766 @default.
• W2912076589 cites W2884753951 @default.
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• W2912076589 doi "https://doi.org/10.1097/j.pain.0000000000001512" @default.
• W2912076589 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6527475" @default.
• W2912076589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30720585" @default.
• W2912076589 hasPublicationYear "2019" @default.
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