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- W2912077016 endingPage "100506" @default.
- W2912077016 startingPage "100506" @default.
- W2912077016 abstract "Zika virus (ZIKV) is an arbovirus belonging to the Flaviviridae family and the genus Flavivirus. Infection with ZIKV causes a mild, self-limiting febrile illness called Zika fever. However, ZIKV infection has been recently associated with microcephaly and Guillain-Barré syndrome. Vaccines for the disease are a high priority of World Health Organization. Several studies are currently being conducted to develop a vaccine against ZIKV, but until now there is no licensed ZIKV vaccine. This study used a novel immunoinformatics approach to identify potential T-cell immunogenic epitopes present in the structural and nonstructural proteins of ZIKV. Fourteen T-cell candidate epitopes were identified on ZIKV structural and nonstructural proteins: pr36-50; C61-75; C103-117; E374-382; E477-491; NS2a90-104; NS2a174-188; NS2a179-193; NS2a190-204; NS2a195-209; NS2a200-214; NS3175-189; and NS4a82-96; NS4a99-113. Among these epitopes, only E374-382 is a human leukocyte antigen (HLA) type I restricted epitope. All identified epitopes showed a low similarity with other important flaviviruses but had a high conservation rate among the ZIKV strains and a high population coverage rate. Therefore, these predicted T-cell epitopes are potential candidates targets for development of vaccines to prevent ZIKV infection." @default.
- W2912077016 created "2019-02-21" @default.
- W2912077016 creator A5022584015 @default.
- W2912077016 creator A5040347858 @default.
- W2912077016 creator A5046680564 @default.
- W2912077016 creator A5046820252 @default.
- W2912077016 creator A5083153237 @default.
- W2912077016 date "2019-05-01" @default.
- W2912077016 modified "2023-09-29" @default.
- W2912077016 title "Identification of relevant regions on structural and nonstructural proteins of Zika virus for vaccine and diagnostic test development: an in silico approach" @default.
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- W2912077016 doi "https://doi.org/10.1016/j.nmni.2019.01.002" @default.
- W2912077016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6396434" @default.
- W2912077016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30858979" @default.
- W2912077016 hasPublicationYear "2019" @default.