Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912077109> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2912077109 endingPage "S1076" @default.
- W2912077109 startingPage "S1075" @default.
- W2912077109 abstract "Intestinal Spirochetosis is a condition marked by anaerobic spirochetes adherence and colonization of the luminal surface of colonic epithelium with occasional penetration into the epithelium. Most cases are found incidentally on pathological evaluation of colonic biopsies taken during diagnostic or therapeutic colonoscopies. However, whether the colonization of the intestinal mucosa can be attributed to clinical symptoms is a matter of debate. Here we present a case of intermittent hematochezia due to invasion of the colonic mucosa by intestinal spirochetes. A 27 year old male with no medical history presented with four days of atypical chest pain and syncope the day prior to presentation. He also reported watery diarrhea and intermittent hematochezia for the past two weeks. A complete cardiovascular and neurologic workup was unremarkable. After a spontaneous episode of painless hematochezia he was found to have a decrease in Hgb from 14 g/dl to 10 g/dl. CRP was 6.5 and ESR was 60. All stool studies, including Clostridium difficile toxin were negative. Coagulation studies were within normal limits. Physical exam was unremarkable except for guaiac positive stool. Colonoscopy was performed, revealing mild erythematous mucosa of the terminal ileum, and a localized area of severely congested, erythematous and inflamed mucosa in the rectum. Random biopsies were taken. Intestinal spirochetes were found in biopsies of the ascending colon, transverse colon, descending colon, sigmoid colon, rectum, and cecum. Terminal ileum and rectum biopsies showed nonspecific inflammatory changes. The overwhelming spirochete invasion suggested these changes were secondary to the infectious process. Screening for all sexually transmitted diseases was negative. He was treated with metronidazole and improvement in symptoms was reported. This case demonstrates that invasive IS may develop in healthy individuals. Although many cases of asymptomatic IS have been described, cases leading to severe gastrointestinal symptoms are rare. No current methods exist to prove a direct relationship between histologic findings of IS and active disease thus leaving IS as the diagnosis of exclusion. Diagnosis requires random colonic biopsies followed by direct visualization via histologic staining, and may be confirmed by fluorescence in situ hybridization. Treatment of IS is controversial and ultimately should be dictated by the presence of symptoms, after all other etiologies have been ruled out.Figure: Erythematous Colonic Mucosa.Figure: False Brush Border Intestinal Colonization of Spirochetes along the colonic epithelium." @default.
- W2912077109 created "2019-02-21" @default.
- W2912077109 creator A5005992644 @default.
- W2912077109 creator A5014224596 @default.
- W2912077109 creator A5016227073 @default.
- W2912077109 creator A5019781698 @default.
- W2912077109 creator A5059207347 @default.
- W2912077109 date "2017-10-01" @default.
- W2912077109 modified "2023-10-18" @default.
- W2912077109 title "Intestinal Spirochetosis: An Obscure Cause of Lower Gastrointestinal Bleeding" @default.
- W2912077109 doi "https://doi.org/10.14309/00000434-201710001-01945" @default.
- W2912077109 hasPublicationYear "2017" @default.
- W2912077109 type Work @default.
- W2912077109 sameAs 2912077109 @default.
- W2912077109 citedByCount "0" @default.
- W2912077109 crossrefType "journal-article" @default.
- W2912077109 hasAuthorship W2912077109A5005992644 @default.
- W2912077109 hasAuthorship W2912077109A5014224596 @default.
- W2912077109 hasAuthorship W2912077109A5016227073 @default.
- W2912077109 hasAuthorship W2912077109A5019781698 @default.
- W2912077109 hasAuthorship W2912077109A5059207347 @default.
- W2912077109 hasBestOaLocation W29120771092 @default.
- W2912077109 hasConcept C121608353 @default.
- W2912077109 hasConcept C126322002 @default.
- W2912077109 hasConcept C142724271 @default.
- W2912077109 hasConcept C2776870353 @default.
- W2912077109 hasConcept C2777226302 @default.
- W2912077109 hasConcept C2777507495 @default.
- W2912077109 hasConcept C2777807078 @default.
- W2912077109 hasConcept C2778292851 @default.
- W2912077109 hasConcept C2778435480 @default.
- W2912077109 hasConcept C2779802037 @default.
- W2912077109 hasConcept C2780833581 @default.
- W2912077109 hasConcept C2781054515 @default.
- W2912077109 hasConcept C2781074409 @default.
- W2912077109 hasConcept C3019368612 @default.
- W2912077109 hasConcept C526805850 @default.
- W2912077109 hasConcept C71924100 @default.
- W2912077109 hasConcept C90924648 @default.
- W2912077109 hasConceptScore W2912077109C121608353 @default.
- W2912077109 hasConceptScore W2912077109C126322002 @default.
- W2912077109 hasConceptScore W2912077109C142724271 @default.
- W2912077109 hasConceptScore W2912077109C2776870353 @default.
- W2912077109 hasConceptScore W2912077109C2777226302 @default.
- W2912077109 hasConceptScore W2912077109C2777507495 @default.
- W2912077109 hasConceptScore W2912077109C2777807078 @default.
- W2912077109 hasConceptScore W2912077109C2778292851 @default.
- W2912077109 hasConceptScore W2912077109C2778435480 @default.
- W2912077109 hasConceptScore W2912077109C2779802037 @default.
- W2912077109 hasConceptScore W2912077109C2780833581 @default.
- W2912077109 hasConceptScore W2912077109C2781054515 @default.
- W2912077109 hasConceptScore W2912077109C2781074409 @default.
- W2912077109 hasConceptScore W2912077109C3019368612 @default.
- W2912077109 hasConceptScore W2912077109C526805850 @default.
- W2912077109 hasConceptScore W2912077109C71924100 @default.
- W2912077109 hasConceptScore W2912077109C90924648 @default.
- W2912077109 hasLocation W29120771091 @default.
- W2912077109 hasLocation W29120771092 @default.
- W2912077109 hasOpenAccess W2912077109 @default.
- W2912077109 hasPrimaryLocation W29120771091 @default.
- W2912077109 hasRelatedWork W1979672442 @default.
- W2912077109 hasRelatedWork W1989918753 @default.
- W2912077109 hasRelatedWork W2029679167 @default.
- W2912077109 hasRelatedWork W2044658514 @default.
- W2912077109 hasRelatedWork W2091757794 @default.
- W2912077109 hasRelatedWork W2324955690 @default.
- W2912077109 hasRelatedWork W2333015007 @default.
- W2912077109 hasRelatedWork W2363611241 @default.
- W2912077109 hasRelatedWork W2760365534 @default.
- W2912077109 hasRelatedWork W3112476025 @default.
- W2912077109 hasVolume "112" @default.
- W2912077109 isParatext "false" @default.
- W2912077109 isRetracted "false" @default.
- W2912077109 magId "2912077109" @default.
- W2912077109 workType "article" @default.