FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912077483> ?p ?o ?g. }

• W2912077483 endingPage "107" @default.
• W2912077483 startingPage "97" @default.
• W2912077483 abstract "The suprachiasmatic nucleus of the hypothalamus is the chief circadian pacemaker in the brain, and is entrained to day-night cycles by visual afferents from melanopsin containing retinal ganglion cells via the inferior accessory optic tract. Tracer studies have demonstrated efferents from the suprachiasmatic nucleus projecting to the paraventricular nucleus of the hypothalamus, which in turn project to first-order sympathetic neurons in the intermedio-lateral grey of the spinal cord. Sympathetic projections to the pineal gland trigger the secretion of the sleep inducing hormone melatonin. The current study reports the first demonstration of potential sympathopetal hypothalamic projections involved in circadian regulation in humans with in vivo virtual white matter dissections using probabilistic diffusion tensor imaging (DTI) tractography. Additionally, our data shows a correlation between individual differences in white matter microstructure (measured with fractional anisotropy) and increased daytime sleepiness [measured with the Epworth Sleepiness Scale (ESS, Johns, 1991)]. Sympathopetal connections with the hypothalamus were virtually dissected using designated masks on the optic chiasm, which served as an anatomical landmark for retinal fibres projecting to the suprachiasmatic nucleus, and a waypoint mask on the lateral medulla, where hypothalamic projections to the sympathetic nervous system traverse in humans. Sympathopetal projections were demonstrated in each hemisphere in twenty-six subjects. The tract passed through the suprachiasmatic nucleus of the hypothalamus and its trajectory corresponds to the dorsal longitudinal fasciculus traversing the periaqueductal region and the lateral medulla. White matter microstructure (FA) in the left hemisphere correlated with high scores on the ESS, suggesting an association between circadian pathway white matter microstructure, and increased daytime sleepiness." @default.
• W2912077483 created "2019-02-21" @default.
• W2912077483 creator A5002040910 @default.
• W2912077483 creator A5034762097 @default.
• W2912077483 creator A5074918450 @default.
• W2912077483 date "2020-01-01" @default.
• W2912077483 modified "2023-09-27" @default.
• W2912077483 title "Circadian circuits in humans: White matter microstructure predicts daytime sleepiness" @default.
• W2912077483 cites W1560106330 @default.
• W2912077483 cites W1969714653 @default.
• W2912077483 cites W197066864 @default.
• W2912077483 cites W2000133863 @default.
• W2912077483 cites W2002293846 @default.
• W2912077483 cites W2026049925 @default.
• W2912077483 cites W2031897068 @default.
• W2912077483 cites W2032748682 @default.
• W2912077483 cites W2034169445 @default.
• W2912077483 cites W2040971675 @default.
• W2912077483 cites W2041650809 @default.
• W2912077483 cites W2043460528 @default.
• W2912077483 cites W2057068116 @default.
• W2912077483 cites W2088459975 @default.
• W2912077483 cites W2098242392 @default.
• W2912077483 cites W2121179645 @default.
• W2912077483 cites W2123210135 @default.
• W2912077483 cites W2126919482 @default.
• W2912077483 cites W2141135746 @default.
• W2912077483 cites W2142059961 @default.
• W2912077483 cites W2145544236 @default.
• W2912077483 cites W2149931687 @default.
• W2912077483 doi "https://doi.org/10.1016/j.cortex.2019.01.011" @default.
• W2912077483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31097190" @default.
• W2912077483 hasPublicationYear "2020" @default.
• W2912077483 type Work @default.
• W2912077483 sameAs 2912077483 @default.
• W2912077483 citedByCount "5" @default.
• W2912077483 countsByYear W29120774832022 @default.
• W2912077483 countsByYear W29120774832023 @default.
• W2912077483 crossrefType "journal-article" @default.
• W2912077483 hasAuthorship W2912077483A5002040910 @default.
• W2912077483 hasAuthorship W2912077483A5034762097 @default.
• W2912077483 hasAuthorship W2912077483A5074918450 @default.
• W2912077483 hasBestOaLocation W29120774832 @default.
• W2912077483 hasConcept C105702510 @default.
• W2912077483 hasConcept C121446783 @default.
• W2912077483 hasConcept C126322002 @default.
• W2912077483 hasConcept C126838900 @default.
• W2912077483 hasConcept C143409427 @default.
• W2912077483 hasConcept C169760540 @default.
• W2912077483 hasConcept C2777003273 @default.
• W2912077483 hasConcept C2779317972 @default.
• W2912077483 hasConcept C2781192897 @default.
• W2912077483 hasConcept C71924100 @default.
• W2912077483 hasConcept C86803240 @default.
• W2912077483 hasConceptScore W2912077483C105702510 @default.
• W2912077483 hasConceptScore W2912077483C121446783 @default.
• W2912077483 hasConceptScore W2912077483C126322002 @default.
• W2912077483 hasConceptScore W2912077483C126838900 @default.
• W2912077483 hasConceptScore W2912077483C143409427 @default.
• W2912077483 hasConceptScore W2912077483C169760540 @default.
• W2912077483 hasConceptScore W2912077483C2777003273 @default.
• W2912077483 hasConceptScore W2912077483C2779317972 @default.
• W2912077483 hasConceptScore W2912077483C2781192897 @default.
• W2912077483 hasConceptScore W2912077483C71924100 @default.
• W2912077483 hasConceptScore W2912077483C86803240 @default.
• W2912077483 hasLocation W29120774831 @default.
• W2912077483 hasLocation W29120774832 @default.
• W2912077483 hasOpenAccess W2912077483 @default.
• W2912077483 hasPrimaryLocation W29120774831 @default.
• W2912077483 hasRelatedWork W1495200669 @default.
• W2912077483 hasRelatedWork W1969212446 @default.
• W2912077483 hasRelatedWork W2020616098 @default.
• W2912077483 hasRelatedWork W2023851530 @default.
• W2912077483 hasRelatedWork W2057257905 @default.
• W2912077483 hasRelatedWork W2141401639 @default.
• W2912077483 hasRelatedWork W2142372025 @default.
• W2912077483 hasRelatedWork W2143731957 @default.
• W2912077483 hasRelatedWork W2407746165 @default.
• W2912077483 hasRelatedWork W2594112905 @default.
• W2912077483 hasVolume "122" @default.
• W2912077483 isParatext "false" @default.
• W2912077483 isRetracted "false" @default.
• W2912077483 magId "2912077483" @default.
• W2912077483 workType "article" @default.