FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912078797> ?p ?o ?g. }

• W2912078797 endingPage "429" @default.
• W2912078797 startingPage "417" @default.
• W2912078797 abstract "Cancer therapeutics development has been a challenge due to their untoward side effects and cytotoxicity. Phytochemical anti-cancer drugs have several advantages over chemical chemotherapeutic drugs as they are less cytotoxic and have a greater pharmacological advantage. However, lack of targeting ability limits the use of phytochemicals at a great extent for a successful therapeutic strategy. Gold nanoparticles (AuNPs) have long been used to load the therapeutic cargo and provided significant advantages over conventional chemo-therapeutics. In this present study, we report the synthesis and testing of various biosynthesized AuNPs (b-AuNPs) using naturally derived phytochemicals (Curcumin: Cur, Turmeric: Tur, Quercetin: Qu and Paclitaxel: Pacli). The synthesized b-AuNPs have been well characterized by different Physicochemical techniques. Cytotoxic potential of these b-AuNPs were evaluated in different breast cancer cells either in an individual or in a combination forms. We have observed the maximum therapeutic activity in a combination of all four types of b-AuNPs (AuNPs-Cur, AuNPs-Tur, AuNPs-Qu and AuNPs-Pacli) as compared to their pristine administration. Further, mechanistic studies of these compounds revealed that, combinations of AuNPs-Cur, AuNPs-Tur, AuNPs-Qu and AuNPs-Pacli were significantly effective in inhibiting cell proliferation, apoptosis, angiogenesis, colony formation and spheroid formation predicting a synergistic effect when compared to individual treatment against different breast cancer cell lines (MCF-7 and MDA-MB 231). Interestingly the nanoconjugates alone or in combinations did not show cytotoxicity towards human embryonic normal kidney cell line (HEK 293), demonstrating the biocompatibility. Together the results demonstrated the potential anti-cancer properties of b-AuNPs in a combinatorial approach that could be the future of cancer nanomedicine." @default.
• W2912078797 created "2019-02-21" @default.
• W2912078797 creator A5003099400 @default.
• W2912078797 creator A5028009066 @default.
• W2912078797 creator A5036201261 @default.
• W2912078797 creator A5072339451 @default.
• W2912078797 creator A5076020750 @default.
• W2912078797 creator A5081100739 @default.
• W2912078797 creator A5034583426 @default.
• W2912078797 date "2019-06-01" @default.
• W2912078797 modified "2023-10-13" @default.
• W2912078797 title "Novel biosynthesized gold nanoparticles as anti-cancer agents against breast cancer: Synthesis, biological evaluation, molecular modelling studies" @default.
• W2912078797 cites W1564674105 @default.
• W2912078797 cites W1571020672 @default.
• W2912078797 cites W1591187753 @default.
• W2912078797 cites W1946759281 @default.
• W2912078797 cites W1969615301 @default.
• W2912078797 cites W1975611419 @default.
• W2912078797 cites W1982397837 @default.
• W2912078797 cites W1984833201 @default.
• W2912078797 cites W2010065712 @default.
• W2912078797 cites W2022766929 @default.
• W2912078797 cites W2039261753 @default.
• W2912078797 cites W2050823452 @default.
• W2912078797 cites W2061106916 @default.
• W2912078797 cites W2070878775 @default.
• W2912078797 cites W2094599199 @default.
• W2912078797 cites W2101520349 @default.
• W2912078797 cites W2118567887 @default.
• W2912078797 cites W2123528875 @default.
• W2912078797 cites W2127992833 @default.
• W2912078797 cites W2144701362 @default.
• W2912078797 cites W2146092806 @default.
• W2912078797 cites W2149967205 @default.
• W2912078797 cites W2151055760 @default.
• W2912078797 cites W2154346380 @default.
• W2912078797 cites W2158168253 @default.
• W2912078797 cites W2268492365 @default.
• W2912078797 cites W2355399472 @default.
• W2912078797 cites W2418464201 @default.
• W2912078797 cites W2463771618 @default.
• W2912078797 cites W2513414068 @default.
• W2912078797 cites W2554511648 @default.
• W2912078797 cites W2592717980 @default.
• W2912078797 cites W2603320479 @default.
• W2912078797 cites W2613285818 @default.
• W2912078797 cites W2618269889 @default.
• W2912078797 cites W2724290859 @default.
• W2912078797 cites W2741562284 @default.
• W2912078797 doi "https://doi.org/10.1016/j.msec.2019.01.123" @default.
• W2912078797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30889716" @default.
• W2912078797 hasPublicationYear "2019" @default.
• W2912078797 type Work @default.
• W2912078797 sameAs 2912078797 @default.
• W2912078797 citedByCount "69" @default.
• W2912078797 countsByYear W29120787972019 @default.
• W2912078797 countsByYear W29120787972020 @default.
• W2912078797 countsByYear W29120787972021 @default.
• W2912078797 countsByYear W29120787972022 @default.
• W2912078797 countsByYear W29120787972023 @default.
• W2912078797 crossrefType "journal-article" @default.
• W2912078797 hasAuthorship W2912078797A5003099400 @default.
• W2912078797 hasAuthorship W2912078797A5028009066 @default.
• W2912078797 hasAuthorship W2912078797A5034583426 @default.
• W2912078797 hasAuthorship W2912078797A5036201261 @default.
• W2912078797 hasAuthorship W2912078797A5072339451 @default.
• W2912078797 hasAuthorship W2912078797A5076020750 @default.
• W2912078797 hasAuthorship W2912078797A5081100739 @default.
• W2912078797 hasConcept C104819515 @default.
• W2912078797 hasConcept C109316439 @default.
• W2912078797 hasConcept C121608353 @default.
• W2912078797 hasConcept C126322002 @default.
• W2912078797 hasConcept C155672457 @default.
• W2912078797 hasConcept C171250308 @default.
• W2912078797 hasConcept C185592680 @default.
• W2912078797 hasConcept C192562407 @default.
• W2912078797 hasConcept C195475562 @default.
• W2912078797 hasConcept C202751555 @default.
• W2912078797 hasConcept C2777292972 @default.
• W2912078797 hasConcept C2778250585 @default.
• W2912078797 hasConcept C2780394083 @default.
• W2912078797 hasConcept C502942594 @default.
• W2912078797 hasConcept C55493867 @default.
• W2912078797 hasConcept C71924100 @default.
• W2912078797 hasConcept C86803240 @default.
• W2912078797 hasConcept C96232424 @default.
• W2912078797 hasConcept C98274493 @default.
• W2912078797 hasConceptScore W2912078797C104819515 @default.
• W2912078797 hasConceptScore W2912078797C109316439 @default.
• W2912078797 hasConceptScore W2912078797C121608353 @default.
• W2912078797 hasConceptScore W2912078797C126322002 @default.
• W2912078797 hasConceptScore W2912078797C155672457 @default.
• W2912078797 hasConceptScore W2912078797C171250308 @default.
• W2912078797 hasConceptScore W2912078797C185592680 @default.
• W2912078797 hasConceptScore W2912078797C192562407 @default.
• W2912078797 hasConceptScore W2912078797C195475562 @default.
• W2912078797 hasConceptScore W2912078797C202751555 @default.
• W2912078797 hasConceptScore W2912078797C2777292972 @default.

• next