FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912081542> ?p ?o ?g. }

• W2912081542 endingPage "799" @default.
• W2912081542 startingPage "788" @default.
• W2912081542 abstract "Farrerol has been shown to have antioxidative potential via Nrf2 activation, which in turn is involved in the prevention of hepatotoxicity. The purpose of the current study was to explore the protective effect of farrerol against acetaminophen-induced hepatotoxicity and its underlying mechanisms. Mice were used to evaluate the hepatoprotective effect of farrerol on liver injury induced by acetaminophen in vivo. HepG2 cells were utilized to further determine the functional role and mechanisms by which Nrf2 and autophagy are involved in the hepatoprotective effect of farrerol in vitro. We found that treatment with farrerol leads to a significant reduction in acetaminophen-induced hepatotoxicity by decreasing mortality, histopathological liver changes, and ALT and AST levels. Furthermore, farrerol effectively suppressed mitochondrial dysfunction by reducing JNK phosphorylation, Bax mitochondrial translocation, AIF and cytochrome c release. Further investigations revealed that the activation of Nrf2 and the induction of autophagy via the AMPK/AKT pathway by farrerol contributed to its hepatoprotective activity in vitro. In addition, farrerol inhibited acetaminophen-induced the mortality and histopathological changes in WT mice were evidently alleviated but not abrogated in Nrf2 -/- mice, which attributed to the induction of autophagy. Together, farrerol has protective potential against acetaminophen-induced hepatotoxicity which may be associated with activation of Nrf2 and autophagy." @default.
• W2912081542 created "2019-02-21" @default.
• W2912081542 creator A5003799076 @default.
• W2912081542 creator A5025837702 @default.
• W2912081542 creator A5065448792 @default.
• W2912081542 creator A5066223731 @default.
• W2912081542 creator A5079654931 @default.
• W2912081542 date "2019-01-01" @default.
• W2912081542 modified "2023-10-04" @default.
• W2912081542 title "Farrerol Ameliorates APAP-induced Hepatotoxicity via Activation of Nrf2 and Autophagy" @default.
• W2912081542 cites W1538831726 @default.
• W2912081542 cites W1571905721 @default.
• W2912081542 cites W1997878364 @default.
• W2912081542 cites W2018123263 @default.
• W2912081542 cites W2056651281 @default.
• W2912081542 cites W2070740941 @default.
• W2912081542 cites W2073224154 @default.
• W2912081542 cites W2074545478 @default.
• W2912081542 cites W2078894330 @default.
• W2912081542 cites W2079350327 @default.
• W2912081542 cites W2100123437 @default.
• W2912081542 cites W2101962482 @default.
• W2912081542 cites W2111834129 @default.
• W2912081542 cites W2137577984 @default.
• W2912081542 cites W2345755899 @default.
• W2912081542 cites W2529405505 @default.
• W2912081542 cites W2541345182 @default.
• W2912081542 cites W2548618596 @default.
• W2912081542 cites W2587071874 @default.
• W2912081542 cites W2592327439 @default.
• W2912081542 cites W2614075325 @default.
• W2912081542 cites W2617388507 @default.
• W2912081542 cites W2792279154 @default.
• W2912081542 cites W2797201060 @default.
• W2912081542 cites W2800988230 @default.
• W2912081542 doi "https://doi.org/10.7150/ijbs.30677" @default.
• W2912081542 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6429022" @default.
• W2912081542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30906210" @default.
• W2912081542 hasPublicationYear "2019" @default.
• W2912081542 type Work @default.
• W2912081542 sameAs 2912081542 @default.
• W2912081542 citedByCount "35" @default.
• W2912081542 countsByYear W29120815422019 @default.
• W2912081542 countsByYear W29120815422020 @default.
• W2912081542 countsByYear W29120815422021 @default.
• W2912081542 countsByYear W29120815422022 @default.
• W2912081542 countsByYear W29120815422023 @default.
• W2912081542 crossrefType "journal-article" @default.
• W2912081542 hasAuthorship W2912081542A5003799076 @default.
• W2912081542 hasAuthorship W2912081542A5025837702 @default.
• W2912081542 hasAuthorship W2912081542A5065448792 @default.
• W2912081542 hasAuthorship W2912081542A5066223731 @default.
• W2912081542 hasAuthorship W2912081542A5079654931 @default.
• W2912081542 hasBestOaLocation W29120815421 @default.
• W2912081542 hasConcept C11960822 @default.
• W2912081542 hasConcept C150903083 @default.
• W2912081542 hasConcept C185592680 @default.
• W2912081542 hasConcept C190283241 @default.
• W2912081542 hasConcept C203522944 @default.
• W2912081542 hasConcept C207001950 @default.
• W2912081542 hasConcept C2776637226 @default.
• W2912081542 hasConcept C2778722691 @default.
• W2912081542 hasConcept C2780124434 @default.
• W2912081542 hasConcept C55493867 @default.
• W2912081542 hasConcept C71924100 @default.
• W2912081542 hasConcept C86803240 @default.
• W2912081542 hasConcept C97029542 @default.
• W2912081542 hasConcept C98274493 @default.
• W2912081542 hasConceptScore W2912081542C11960822 @default.
• W2912081542 hasConceptScore W2912081542C150903083 @default.
• W2912081542 hasConceptScore W2912081542C185592680 @default.
• W2912081542 hasConceptScore W2912081542C190283241 @default.
• W2912081542 hasConceptScore W2912081542C203522944 @default.
• W2912081542 hasConceptScore W2912081542C207001950 @default.
• W2912081542 hasConceptScore W2912081542C2776637226 @default.
• W2912081542 hasConceptScore W2912081542C2778722691 @default.
• W2912081542 hasConceptScore W2912081542C2780124434 @default.
• W2912081542 hasConceptScore W2912081542C55493867 @default.
• W2912081542 hasConceptScore W2912081542C71924100 @default.
• W2912081542 hasConceptScore W2912081542C86803240 @default.
• W2912081542 hasConceptScore W2912081542C97029542 @default.
• W2912081542 hasConceptScore W2912081542C98274493 @default.
• W2912081542 hasIssue "4" @default.
• W2912081542 hasLocation W29120815421 @default.
• W2912081542 hasLocation W29120815422 @default.
• W2912081542 hasLocation W29120815423 @default.
• W2912081542 hasLocation W29120815424 @default.
• W2912081542 hasOpenAccess W2912081542 @default.
• W2912081542 hasPrimaryLocation W29120815421 @default.
• W2912081542 hasRelatedWork W1964958658 @default.
• W2912081542 hasRelatedWork W2325672943 @default.
• W2912081542 hasRelatedWork W2802007623 @default.
• W2912081542 hasRelatedWork W2806491969 @default.
• W2912081542 hasRelatedWork W2883873516 @default.
• W2912081542 hasRelatedWork W2887432027 @default.
• W2912081542 hasRelatedWork W3034638657 @default.
• W2912081542 hasRelatedWork W3104081815 @default.
• W2912081542 hasRelatedWork W4297073055 @default.

• next