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• W2912082264 endingPage "28" @default.
• W2912082264 startingPage "28" @default.
• W2912082264 abstract "Although the branched capsular polysaccharides of Streptococcus agalactiae serotype III (GBSIII PS) and Streptococcus pneumoniae serotype 14 (Pn14 PS) differ only in the addition of a terminal sialic acid on the GBSIII PS side chains, these very similar polysaccharides are immunogenically distinct. Our simulations of GBSIII PS, Pn14 PS and the unbranched backbone polysaccharide provide a conformational rationale for the different antigenic epitopes identified for these PS. We find that side chains stabilize the proximal β dGlc(1→6) β dGlcNAc backbone linkage, restricting rotation and creating a well-defined conformational epitope at the branch point. This agrees with the glycotope structure recognized by an anti-GBSIII PS functional monoclonal antibody. We find the same dominant solution conformation for GBSIII and Pn14 PS: aside from the branch point, the backbone is very flexible with a “zig-zag” conformational habit, rather than the helix previously proposed for GBSIII PS. This suggests a common strategy for bacterial evasion of the host immune system: a flexible backbone that is less perceptible to the immune system, combined with conformationally-defined branch points presenting human-mimic epitopes. This work demonstrates how small structural features such as side chains can alter the conformation of a polysaccharide by restricting rotation around backbone linkages." @default.
• W2912082264 created "2019-02-21" @default.
• W2912082264 creator A5019463174 @default.
• W2912082264 creator A5044050205 @default.
• W2912082264 date "2019-02-13" @default.
• W2912082264 modified "2023-09-25" @default.
• W2912082264 title "Conformation and Cross-Protection in Group B Streptococcus Serotype III and Streptococcus pneumoniae Serotype 14: A Molecular Modeling Study" @default.
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• W2912082264 doi "https://doi.org/10.3390/ph12010028" @default.
• W2912082264 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6469160" @default.
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• W2912082264 hasPublicationYear "2019" @default.
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