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- W2912083622 endingPage "1200" @default.
- W2912083622 startingPage "1191" @default.
- W2912083622 abstract "Abstract Approximately 35% to 50% of patients otherwise cured of hematologic malignancies after allogeneic hematopoietic stem cell transplantation will develop the pleomorphic autoimmune-like syndrome known as chronic graft-versus-host disease (cGVHD). Since in 2005, National Institutes of Health (NIH) consensus panels have proposed definitions and classifications of disease to standardize treatment trials. Recently, the first agent was approved by the US Food and Drug Administration for steroid-refractory cGVHD. Despite these advances, most individuals do not achieve durable resolution of disease activity with initial treatment. Moreover, standardized recommendations on how to best implement existing and novel immunomodulatory agents and taper salvage agents are often lacking. Given the potential life-threatening nature of cGVHD, we employ in our practice patient assessment templates at each clinic visit to elucidate known prognostic indicators and red flags. We find NIH scoring templates practical for ongoing assessments of these complex patient cases and determination of when changes in immunosuppressive therapy are warranted. Patients not eligible or suitable for clinical trials have systemic and organ-directed adjunctive treatments crafted in a multidisciplinary clinic. Herein, we review these treatment options and offer a management and monitoring scaffold for representative patients with cGVHD not responding to initial therapy." @default.
- W2912083622 created "2019-02-21" @default.
- W2912083622 creator A5037247107 @default.
- W2912083622 creator A5064235364 @default.
- W2912083622 creator A5077581687 @default.
- W2912083622 date "2019-03-14" @default.
- W2912083622 modified "2023-10-10" @default.
- W2912083622 title "How I treat refractory chronic graft-versus-host disease" @default.
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