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- W2912084317 abstract "Introduction: Childhood leukaemia (CL) is the most frequent paediatric cancer but its aetiology remains largely unknown. A number of studies have investigated whether CL cases cluster in space and time, but to date there has been no systematic synthesis of this evidence. We performed a systematic review and propose a method for meta-analysing studies using the Knox test, the most common test statistic to assess space-time clustering of CL. Methods: We searched for studies assessing space-time clustering of CL based on residence at birth or diagnosis. The Knox test statistic T, i.e. the number of pairs of cases lying within a given spatial and temporal lag from each other, is assumed to be approximately Poisson distributed and its square root (√T) thus approximately normally distributed with constant variance. We propose meta-analysing √T/√E, where E is the expectation of T in the absence of clustering. We performed a random effects meta-analysis for spatial and temporal lags closest to the mean lag values over all included studies and subgroup analyses for different combinations of spatial and temporal lags for which a minimum of four studies could be included. Analyses were performed separately for residence at birth and diagnosis for children aged 0-15 and 0-5 years old. Results: We included 19 and 10 studies of residence at diagnosis and birth, respectively. There was evidence of space-time clustering of CL at diagnosis for ages 0-5 years (p=0.039). The clustering effect was strongest at space-time lags of 5 km and 6 months (p<0.001). At the time of birth, we observed marginally significant clustering for ages 0-5 years (p=0.064). Conclusion: The results of our meta-analysis suggest that cases of CL aged 0-5 years tend to cluster in space and time due to an aetiological factor acting close to the time of diagnosis. However, due to selective reporting in the included studies, our findings must be interpreted with caution." @default.
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- W2912084317 date "2016-08-17" @default.
- W2912084317 modified "2023-09-28" @default.
- W2912084317 title "Space-time Clustering of Childhood Leukaemia: A Systematic Review and Meta-Analysis" @default.
- W2912084317 doi "https://doi.org/10.1289/isee.2016.4301" @default.
- W2912084317 hasPublicationYear "2016" @default.
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