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• W2912086353 abstract "Stick-slip motion, a common phenomenon observed during crawling of cells, is found to be strongly sensitive to the substrate stiffness. Stick-slip behaviours have previously been investigated typically using purely elastic substrates. For a more realistic understanding of this phenomenon, we propose a theoretical model to study the dynamics on a viscoelastic substrate. Our model based on a reaction-diffusion framework, incorporates known important interactions such as retrograde flow of actin, myosin contractility, force dependent assembly and disassembly of focal adhesions coupled with cell-substrate interaction. We show that consideration of a viscoelastic substrate not only captures the usually observed stick-slip jumps, but also predicts the existence of an optimal substrate viscosity corresponding to maximum traction force and minimum retrograde flow which was hitherto unexplored. Moreover, our theory predicts the time evolution of individual bond force that characterizes the stick-slip patterns on soft versus stiff substrates. Our analysis also elucidates how the duration of the stick-slip cycles are affected by various cellular parameters." @default.
• W2912086353 created "2019-02-21" @default.
• W2912086353 creator A5035592127 @default.
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• W2912086353 date "2019-07-26" @default.
• W2912086353 modified "2023-09-30" @default.
• W2912086353 title "Stick-slip dynamics of migrating cells on viscoelastic substrates" @default.
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• W2912086353 doi "https://doi.org/10.1103/physreve.100.012409" @default.
• W2912086353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31499904" @default.
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