FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912090477> ?p ?o ?g. }

• W2912090477 abstract "Genome-wide association studies (GWAS) have been successful in identifying disease-associated genetic variants. Recently, an increasing number of GWAS summary statistics have been made available to the research community, providing extensive repositories for studies of human complex diseases. In particular, cross-trait associations at the genetic level can be beneficial from large-scale GWAS summary statistics by using genetic variants that are associated with multiple traits. However, direct assessment of cross-trait associations using susceptibility loci has been challenging due to the complex genetic architectures in most diseases, calling for advantageous methods that could integrate functional interpretation and imply biological mechanisms. We developed an analytical framework for systematic integration of cross-trait associations. It incorporates two different approaches to detect enriched pathways and requires only summary statistics. We demonstrated the framework using 25 traits belonging to four phenotype groups. Our results revealed an average of 54 significantly associated pathways (ranged between 18 and 175) per trait. We further proved that pathway-based analysis provided increased power to estimate cross-trait associations compared to gene-level analysis. Based on Fisher’s Exact Test (FET), we identified a total of 24 (53) pairs of trait-trait association at adjusted pFET < 1 × 10− 3 (pFET < 0.01) among the 25 traits. Our trait-trait association network revealed not only many relationships among the traits within the same group but also novel relationships among traits from different groups, which warrants further investigation in future. Our study revealed that risk variants for 25 different traits aggregated in particular biological pathways and that these pathways were frequently shared among traits. Our results confirmed known mechanisms and also suggested several novel insights into the etiology of multi-traits." @default.
• W2912090477 created "2019-02-21" @default.
• W2912090477 creator A5006688612 @default.
• W2912090477 creator A5043473632 @default.
• W2912090477 creator A5055086139 @default.
• W2912090477 creator A5056121087 @default.
• W2912090477 creator A5056674934 @default.
• W2912090477 creator A5080628294 @default.
• W2912090477 date "2019-02-01" @default.
• W2912090477 modified "2023-10-18" @default.
• W2912090477 title "Investigation of multi-trait associations using pathway-based analysis of GWAS summary statistics" @default.
• W2912090477 cites W1589554927 @default.
• W2912090477 cites W1879002358 @default.
• W2912090477 cites W1952270405 @default.
• W2912090477 cites W1986818660 @default.
• W2912090477 cites W1988404229 @default.
• W2912090477 cites W1990160261 @default.
• W2912090477 cites W1991160835 @default.
• W2912090477 cites W1996299724 @default.
• W2912090477 cites W1999218213 @default.
• W2912090477 cites W2014862380 @default.
• W2912090477 cites W2021703037 @default.
• W2912090477 cites W2041142457 @default.
• W2912090477 cites W2057223854 @default.
• W2912090477 cites W2075199575 @default.
• W2912090477 cites W2077646289 @default.
• W2912090477 cites W2089114442 @default.
• W2912090477 cites W2097099463 @default.
• W2912090477 cites W2102181001 @default.
• W2912090477 cites W2103606272 @default.
• W2912090477 cites W2108858638 @default.
• W2912090477 cites W2110549414 @default.
• W2912090477 cites W2117446594 @default.
• W2912090477 cites W2126609769 @default.
• W2912090477 cites W2129031013 @default.
• W2912090477 cites W2132934020 @default.
• W2912090477 cites W2136322773 @default.
• W2912090477 cites W2137031864 @default.
• W2912090477 cites W2149098364 @default.
• W2912090477 cites W2150472995 @default.
• W2912090477 cites W2152325859 @default.
• W2912090477 cites W2195783463 @default.
• W2912090477 cites W2254879037 @default.
• W2912090477 cites W2293522653 @default.
• W2912090477 cites W2330978860 @default.
• W2912090477 cites W2396108650 @default.
• W2912090477 cites W2401811918 @default.
• W2912090477 cites W2547876355 @default.
• W2912090477 cites W2553123256 @default.
• W2912090477 cites W2559028527 @default.
• W2912090477 cites W2591470648 @default.
• W2912090477 cites W2621210046 @default.
• W2912090477 cites W2623056867 @default.
• W2912090477 cites W2759138094 @default.
• W2912090477 cites W2761294215 @default.
• W2912090477 cites W2766896210 @default.
• W2912090477 cites W2773669559 @default.
• W2912090477 cites W2792688330 @default.
• W2912090477 cites W2794001494 @default.
• W2912090477 cites W2794165852 @default.
• W2912090477 cites W4235887661 @default.
• W2912090477 doi "https://doi.org/10.1186/s12864-018-5373-7" @default.
• W2912090477 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6360716" @default.
• W2912090477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30712509" @default.
• W2912090477 hasPublicationYear "2019" @default.
• W2912090477 type Work @default.
• W2912090477 sameAs 2912090477 @default.
• W2912090477 citedByCount "15" @default.
• W2912090477 countsByYear W29120904772019 @default.
• W2912090477 countsByYear W29120904772020 @default.
• W2912090477 countsByYear W29120904772021 @default.
• W2912090477 countsByYear W29120904772022 @default.
• W2912090477 countsByYear W29120904772023 @default.
• W2912090477 crossrefType "journal-article" @default.
• W2912090477 hasAuthorship W2912090477A5006688612 @default.
• W2912090477 hasAuthorship W2912090477A5043473632 @default.
• W2912090477 hasAuthorship W2912090477A5055086139 @default.
• W2912090477 hasAuthorship W2912090477A5056121087 @default.
• W2912090477 hasAuthorship W2912090477A5056674934 @default.
• W2912090477 hasAuthorship W2912090477A5080628294 @default.
• W2912090477 hasBestOaLocation W29120904771 @default.
• W2912090477 hasConcept C104317684 @default.
• W2912090477 hasConcept C105795698 @default.
• W2912090477 hasConcept C106208931 @default.
• W2912090477 hasConcept C106934330 @default.
• W2912090477 hasConcept C135763542 @default.
• W2912090477 hasConcept C142853389 @default.
• W2912090477 hasConcept C153209595 @default.
• W2912090477 hasConcept C15744967 @default.
• W2912090477 hasConcept C186413461 @default.
• W2912090477 hasConcept C199360897 @default.
• W2912090477 hasConcept C32792767 @default.
• W2912090477 hasConcept C33923547 @default.
• W2912090477 hasConcept C41008148 @default.
• W2912090477 hasConcept C542102704 @default.
• W2912090477 hasConcept C54355233 @default.
• W2912090477 hasConcept C70721500 @default.
• W2912090477 hasConcept C81941488 @default.
• W2912090477 hasConcept C86803240 @default.
• W2912090477 hasConcept C9287583 @default.

• next