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• W2912090653 abstract "Objective To retrospectively evaluate the value of MR features based on Liver Imaging Reporting and Data System (LI-RADS ver.2017) for identifying the status of cytokeratin (CK) 19 expression of HCC before surgery. Methods A total of 201 patients with 207 HCCs who underwent MR imaging were reviewed retrospectively. MR features based on LI-RADS ver.2017 as well as clinical data were compared between CK19-positive (n = 51) and CK19-negative (n = 156) HCCs groups. Potential predictive parameters were identified by univariate and multivariate logistic regression analysis and diagnostic odds ratios (ORs) were recorded. Results MR features including targetoid appearance (p = 0.001) was more frequently observed while non-peripheral “washout” (p < 0.0001) and non-rim arterial phase hyper-enhancement (p < 0.0001) were found less frequently in CK19-positive HCCs compared to CK19-negative HCCs. At multivariate analysis, serum alphafetoprotein (AFP)>20 ng/ml (OR = 5.9) and targetoid appearance (OR = 4.2) and non-peripheral “washout” (OR = 0.2) were significant independent predictors of CK19-positive HCCs. Conclusion Targetoid appearance and absence non-peripheral “washout” combined with elevated AFP were useful for differentiating CK19-positive HCCs from CK19-negative HCC." @default.
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• W2912090653 date "2019-04-01" @default.
• W2912090653 modified "2023-10-16" @default.
• W2912090653 title "MR features based on LI-RADS identify cytokeratin 19 status of hepatocellular carcinomas" @default.
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• W2912090653 doi "https://doi.org/10.1016/j.ejrad.2019.01.036" @default.
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