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- W2912092093 endingPage "333" @default.
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- W2912092093 abstract "Introduction: Inherited arrhythmias are an uncommon, but malignant family of cardiac diseases that result from genetic abnormalities in the ion channels and/or structural proteins within cardiomyocytes. Given the inherent differences between species and the limited reproducibility of in vitro heterologous cell models, progress in understanding the mechanisms underlying these malignant diseases has always languished far behind the clinical science and need. The ability to study human induced pluripotent stem cells (iPSCs) derived cardiomyocytes promises to change this paradigm as patient cells have the potential to become testing platforms for disease phenotyping or therapeutic discovery.Areas covered: This review will outline methods developed to genetically reprogram adult cells into iPSCs, differentiate iPSCs into ex vivo models of adult cardiac tissue and iPSCs-based progress in exploring the mechanisms underlying pro-arrhythmic disease phenotypes.Expert opinion: Despite being discovered less than 15 years ago, several studies have successfully leveraged iPSCs-derived cardiomyocytes to study malignant arrhythmogenic diseases. These models promise to increase our understanding of the pathophysiology underlying these complex diseases and may identify personalized approaches to treatment." @default.
- W2912092093 created "2019-02-21" @default.
- W2912092093 creator A5007490948 @default.
- W2912092093 creator A5030732786 @default.
- W2912092093 creator A5062520932 @default.
- W2912092093 creator A5084800413 @default.
- W2912092093 date "2019-02-07" @default.
- W2912092093 modified "2023-10-10" @default.
- W2912092093 title "Disease modeling of cardiac arrhythmias using human induced pluripotent stem cells" @default.
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