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- W2912092571 endingPage "341" @default.
- W2912092571 startingPage "329" @default.
- W2912092571 abstract "Anticancer chemotherapy often faces the problem of intrinsic or acquired drug refractoriness due in part to efficient mechanisms of defense present or developed, respectively, in cancer cells. Owing to their polarity and/or high molecular weight, many cytostatic agents cannot freely cross the plasma membrane by simple diffusion and hence depend on SLC proteins to enter cancer cells. The downregulation of these transporters and the appearance of either inactivating mutations or aberrant splicing, hamper the possibility of anticancer drugs to interact with their intracellular targets. Areas covered: In addition to specific literature, we have revised Gene database of the NCBI PubMed resources and information publicly available at NIH 'The Cancer Genome Atlas' (TCGA) (update November 2018) to evaluate the relationship between the profile of expression of SLC transporters playing a major role in the transportome and accounting for drug uptake, in healthy and tumor tissue, and their ability to recognize as substrate several antitumor drugs frequently used in the treatment of different types of cancer, which could affect the overall response to chemotherapy based on regimens including these drugs. Expert commentary: Changes in the transportome may affect the overall response to chemotherapy based on drugs taken up by SLC transporters." @default.
- W2912092571 created "2019-02-21" @default.
- W2912092571 creator A5005462346 @default.
- W2912092571 creator A5021872552 @default.
- W2912092571 creator A5044490536 @default.
- W2912092571 creator A5046954573 @default.
- W2912092571 creator A5059591779 @default.
- W2912092571 creator A5078818346 @default.
- W2912092571 date "2019-02-26" @default.
- W2912092571 modified "2023-10-18" @default.
- W2912092571 title "Unraveling ‘The Cancer Genome Atlas’ information on the role of SLC transporters in anticancer drug uptake" @default.
- W2912092571 cites W1500281827 @default.
- W2912092571 cites W1547725393 @default.
- W2912092571 cites W1559370499 @default.
- W2912092571 cites W1570715592 @default.
- W2912092571 cites W1788032165 @default.
- W2912092571 cites W1840691103 @default.
- W2912092571 cites W1965064051 @default.
- W2912092571 cites W1968791276 @default.
- W2912092571 cites W1971084882 @default.
- W2912092571 cites W1971901938 @default.
- W2912092571 cites W1975995575 @default.
- W2912092571 cites W1981608445 @default.
- W2912092571 cites W1982331982 @default.
- W2912092571 cites W1984561022 @default.
- W2912092571 cites W1990923121 @default.
- W2912092571 cites W1997696660 @default.
- W2912092571 cites W2000478673 @default.
- W2912092571 cites W2000526346 @default.
- W2912092571 cites W2010355719 @default.
- W2912092571 cites W2015557036 @default.
- W2912092571 cites W2016203478 @default.
- W2912092571 cites W2017094452 @default.
- W2912092571 cites W2017344894 @default.
- W2912092571 cites W2022247717 @default.
- W2912092571 cites W2024302689 @default.
- W2912092571 cites W2031595392 @default.
- W2912092571 cites W2033336789 @default.
- W2912092571 cites W2035401855 @default.
- W2912092571 cites W2037527490 @default.
- W2912092571 cites W2044428726 @default.
- W2912092571 cites W2045681909 @default.
- W2912092571 cites W2045796389 @default.
- W2912092571 cites W2046772180 @default.
- W2912092571 cites W2055366578 @default.
- W2912092571 cites W2061147784 @default.
- W2912092571 cites W2062203984 @default.
- W2912092571 cites W2062764228 @default.
- W2912092571 cites W2063157862 @default.
- W2912092571 cites W2076194172 @default.
- W2912092571 cites W2079528717 @default.
- W2912092571 cites W2084492467 @default.
- W2912092571 cites W2085008263 @default.
- W2912092571 cites W2092012801 @default.
- W2912092571 cites W2092443043 @default.
- W2912092571 cites W2094110689 @default.
- W2912092571 cites W2096758996 @default.
- W2912092571 cites W2097664002 @default.
- W2912092571 cites W2098239437 @default.
- W2912092571 cites W2099044636 @default.
- W2912092571 cites W2100506495 @default.
- W2912092571 cites W2107229047 @default.
- W2912092571 cites W2111224278 @default.
- W2912092571 cites W2113665053 @default.
- W2912092571 cites W2114528819 @default.
- W2912092571 cites W2120475156 @default.
- W2912092571 cites W2122023026 @default.
- W2912092571 cites W2124342265 @default.
- W2912092571 cites W2127539800 @default.
- W2912092571 cites W2133579393 @default.
- W2912092571 cites W2135119861 @default.
- W2912092571 cites W2136698262 @default.
- W2912092571 cites W2139974473 @default.
- W2912092571 cites W2141765564 @default.
- W2912092571 cites W2146553113 @default.
- W2912092571 cites W2148070209 @default.
- W2912092571 cites W2149001407 @default.
- W2912092571 cites W2150869032 @default.
- W2912092571 cites W2154254307 @default.
- W2912092571 cites W2155229204 @default.
- W2912092571 cites W2161428444 @default.
- W2912092571 cites W2167898988 @default.
- W2912092571 cites W2168381076 @default.
- W2912092571 cites W2170326611 @default.
- W2912092571 cites W2175111971 @default.
- W2912092571 cites W2385169442 @default.
- W2912092571 cites W2417554467 @default.
- W2912092571 cites W2558829860 @default.
- W2912092571 cites W2559922842 @default.
- W2912092571 cites W2583669482 @default.
- W2912092571 cites W2588008686 @default.
- W2912092571 cites W2594053278 @default.
- W2912092571 cites W2604196779 @default.
- W2912092571 cites W2604845642 @default.
- W2912092571 cites W2625038809 @default.
- W2912092571 cites W2761659986 @default.
- W2912092571 cites W2765967569 @default.
- W2912092571 cites W2771652721 @default.