Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912095029> ?p ?o ?g. }
- W2912095029 abstract "Abstract G protein-coupled receptors (GPCRs) are the most widely targeted gene family for FDA-approved drugs. To assess possible roles for GPCRs in cancer, we analyzed Cancer Genome Atlas data for mRNA expression, mutations, and copy number variation (CNV) in 20 categories/45 sub-types of solid tumors and quantified differential expression of GPCRs by comparing tumors against normal tissue from the GTEx database. GPCRs are over-represented among coding genes with elevated expression in solid tumors; most tumor types differentially express >50 GPCRs, including many targets for approved drugs, hitherto largely unrecognized as targets of interest in cancer. GPCR mRNA signatures characterize specific tumor types, indicate survival and correlate with expression of cancer-related pathways. Tumor GPCR mRNA signatures have prognostic relevance for survival and correlate with expression of numerous cancer-related genes and pathways. GPCR expression in tumors is largely independent of staging/grading/metastasis/driver mutations and GPCRs expressed in cancer cell lines parallels that measured in tumors. Certain GPCRs are frequently mutated and appear to be hotspots, serving as bellwethers of accumulated genomic damage. CNV of GPCRs while common, does not generally correlate with mRNA expression. We suggest a previously under-appreciated role for GPCRs in cancer, perhaps as functional oncogenes, biomarkers, surface antigens and pharmacological targets." @default.
- W2912095029 created "2019-02-21" @default.
- W2912095029 creator A5004264767 @default.
- W2912095029 creator A5009470472 @default.
- W2912095029 creator A5019745232 @default.
- W2912095029 creator A5054673990 @default.
- W2912095029 creator A5055677266 @default.
- W2912095029 date "2019-02-11" @default.
- W2912095029 modified "2023-10-16" @default.
- W2912095029 title "GPCRs show widespread differential mRNA expression and frequent mutation and copy number variation in solid tumors" @default.
- W2912095029 cites W1529699615 @default.
- W2912095029 cites W1653658786 @default.
- W2912095029 cites W1919600054 @default.
- W2912095029 cites W1964445245 @default.
- W2912095029 cites W1967717472 @default.
- W2912095029 cites W1992290505 @default.
- W2912095029 cites W1998745344 @default.
- W2912095029 cites W1999574084 @default.
- W2912095029 cites W2000189769 @default.
- W2912095029 cites W2004150448 @default.
- W2912095029 cites W2011762933 @default.
- W2912095029 cites W2018838463 @default.
- W2912095029 cites W2022495797 @default.
- W2912095029 cites W2034269086 @default.
- W2912095029 cites W2035350697 @default.
- W2912095029 cites W2038566830 @default.
- W2912095029 cites W2038709562 @default.
- W2912095029 cites W2038809664 @default.
- W2912095029 cites W2042082129 @default.
- W2912095029 cites W2043398720 @default.
- W2912095029 cites W2044275353 @default.
- W2912095029 cites W2045317999 @default.
- W2912095029 cites W2052005627 @default.
- W2912095029 cites W2064520370 @default.
- W2912095029 cites W2069049795 @default.
- W2912095029 cites W2074573190 @default.
- W2912095029 cites W2080580057 @default.
- W2912095029 cites W2082046119 @default.
- W2912095029 cites W2086687315 @default.
- W2912095029 cites W2097990861 @default.
- W2912095029 cites W2114104545 @default.
- W2912095029 cites W2115746733 @default.
- W2912095029 cites W2115801432 @default.
- W2912095029 cites W2122769974 @default.
- W2912095029 cites W2124097252 @default.
- W2912095029 cites W2130410032 @default.
- W2912095029 cites W2139708137 @default.
- W2912095029 cites W2157276028 @default.
- W2912095029 cites W2157852151 @default.
- W2912095029 cites W2159401034 @default.
- W2912095029 cites W2168621245 @default.
- W2912095029 cites W2169456326 @default.
- W2912095029 cites W2173409662 @default.
- W2912095029 cites W2181958706 @default.
- W2912095029 cites W2196303538 @default.
- W2912095029 cites W2206762191 @default.
- W2912095029 cites W2213385499 @default.
- W2912095029 cites W2240242048 @default.
- W2912095029 cites W2272730938 @default.
- W2912095029 cites W2345356016 @default.
- W2912095029 cites W2473593565 @default.
- W2912095029 cites W2493204726 @default.
- W2912095029 cites W2507856777 @default.
- W2912095029 cites W2537262399 @default.
- W2912095029 cites W2537623931 @default.
- W2912095029 cites W2558217333 @default.
- W2912095029 cites W2593737851 @default.
- W2912095029 cites W2604808360 @default.
- W2912095029 cites W2607211817 @default.
- W2912095029 cites W2741191097 @default.
- W2912095029 cites W2752984803 @default.
- W2912095029 cites W2767115634 @default.
- W2912095029 cites W40204338 @default.
- W2912095029 cites W4243087978 @default.
- W2912095029 cites W4294216483 @default.
- W2912095029 doi "https://doi.org/10.1101/546481" @default.
- W2912095029 hasPublicationYear "2019" @default.
- W2912095029 type Work @default.
- W2912095029 sameAs 2912095029 @default.
- W2912095029 citedByCount "3" @default.
- W2912095029 countsByYear W29120950292023 @default.
- W2912095029 crossrefType "posted-content" @default.
- W2912095029 hasAuthorship W2912095029A5004264767 @default.
- W2912095029 hasAuthorship W2912095029A5009470472 @default.
- W2912095029 hasAuthorship W2912095029A5019745232 @default.
- W2912095029 hasAuthorship W2912095029A5054673990 @default.
- W2912095029 hasAuthorship W2912095029A5055677266 @default.
- W2912095029 hasBestOaLocation W29120950291 @default.
- W2912095029 hasConcept C104317684 @default.
- W2912095029 hasConcept C120821319 @default.
- W2912095029 hasConcept C121608353 @default.
- W2912095029 hasConcept C135285700 @default.
- W2912095029 hasConcept C141231307 @default.
- W2912095029 hasConcept C170493617 @default.
- W2912095029 hasConcept C2779013556 @default.
- W2912095029 hasConcept C502942594 @default.
- W2912095029 hasConcept C54355233 @default.
- W2912095029 hasConcept C60644358 @default.
- W2912095029 hasConcept C70721500 @default.
- W2912095029 hasConcept C86803240 @default.