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- W2912095922 abstract "Background: Ulcer patients need to be treated for Helicobacter pylori infection. Seven days of quadruple therapy achieves the highest cure rates. In this study a 4-day quadruple regimen of lansoprazole, bismuth, tetracycline and metronidazole is investigated.Methods: In an open study 66 consecutive infected patients with ulcer disease or non-ulcer dyspepsia were treated with 4-day quadruple therapy after 3 days of lansoprazole pretreatment. H. pylori status was determined before and at least 6 weeks after therapy by endoscopy with antral and corpus biopsies for rapid urease test, histology and culture.Results: Sixty-four patients took the medication and complete compliance was achieved in 60 (94%). Tolerability was excellent and there were no drop-outs due to side-effects. Overall 55 out of 64 (86%, 95%CI 77.4–94.4%) were cured, including 41/44 with a metronidazole-sensitive strain and 5/8 with a resistant strain.Conclusions: Four-day quadruple therapy is well tolerated and very effective especially in metronidazole-sensitive strains. This study lends further support for the use of one-week quadruple therapy as empiric first line anti-Helicobacter therapy for Dutch ulcer patients. If patients suffer from side-effects during this therapy stopping treatment at day 4 can be advised." @default.
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- W2912095922 date "1996-01-01" @default.
- W2912095922 modified "2023-09-26" @default.
- W2912095922 title "and non- bacterial flora before and after eradication therapy for" @default.
- W2912095922 doi "https://doi.org/10.1016/0300-2977(96)89587-8" @default.
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