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• W2912096945 abstract "Abstract Background Cerenkov Luminescence Imaging (CLI) is an emerging technology for intraoperative margin assessment. Previous research only evaluated radionuclide 18-Fluorine ( 18 F); however, for future applications in prostate cancer, 68-Gallium ( 68 Ga) seems more suitable, given its higher positron energy. Theoretical calculations predict that 68 Ga should offer a higher signal-to-noise ratio than 18 F; this is the first experimental confirmation. The aim of this study is to investigate the technical performance of CLI by comparing 68 Ga to 18 F. Results The linearity of the system, detection limit, spatial resolution, and uniformity were determined with the LightPath imaging system. All experiments were conducted with clinically relevant activity levels in vitro, using dedicated phantoms. For both radionuclides, a linear relationship between the activity concentration and detected light yield was observed ( R 2 = 0.99). 68 Ga showed approximately 22 times more detectable Cerenkov signal compared to 18 F. The detectable activity concentration after a 120 s exposure time and 2 × 2 binning of 18 F was 23.7 kBq/mL and 1.2 kBq/mL for 68 Ga. The spatial resolution was 1.31 mm for 18 F and 1.40 mm for 68 Ga. The coefficient of variance of the uniformity phantom was 0.07 for the central field of view. Conclusion 68 Ga was superior over 18 F in terms of light yield and minimal detection limit. However, as could be expected, the resolution was 0.1 mm less for 68 Ga. Given the clinical constraints of an acquisition time less than 120 s and a spatial resolution < 2 mm, CLI for intraoperative margin assessment using 68 Ga could be feasible." @default.
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• W2912096945 date "2019-10-24" @default.
• W2912096945 modified "2023-10-16" @default.
• W2912096945 title "Performance evaluation of Cerenkov luminescence imaging: a comparison of 68Ga with 18F" @default.
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• W2912096945 doi "https://doi.org/10.1186/s40658-019-0255-x" @default.
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