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- W2912097673 abstract "Huntington disease, HD is a progressive neurodegenerative disorder . Some excitatory chemicals released like glutamate which causes the cell damage and the neuron die due to over accumulation of the glutamate in Huntington diseases ( HD ) , which is regulated by the GABA also known as gamma - amino butyric acid, it is a major inhibitory neurotransmitter of the nervous system . Here we are targeting the pyridoxal dependent enzyme which degrades the GABA neurotransmitter, that is g - Amino butyrate aminotransferase ( GABA - AT ). The study comprises of the estimation of inhibitory activity of the ligands against the GABA - AT . The PDB structure of the human GABA - AT is not known so we use pig GABA - AT, as there is a very high sequence similarity between human and pig GABA - AT, the PDB id of protein 1OHV, which is chosen as a target protein . The database of 1687 ligands for GABA - AT was prepared from LigPrep in Schrodinger . Eight compounds with highest binding energy that was identified using precisions like virtual screening with ADME test and leads to acceptable pharmacokinetic properties . These compounds can be treated as inhibitors for symptoms due to HD for in vitro studies . Keywords : Huntington diseases, Glutamate, Gamma - aminobutyric acid, g - Aminobutyrate aminotransferase, Virtual screening, Pharmacokinetic properties Cite this Article Shilpi Verma, Prachi Srivastava, Vivek Verma, et al. In silico potential drug target identification against 4 - aminobutyrate aminotransferase for Huntington diseases. Research & Reviews: A Journal of Drug Design & Discovery . 2017; 4(3): 1–5p." @default.
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- W2912097673 date "2018-03-09" @default.
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- W2912097673 title "In silico potential drug target identification against 4-aminobutyrate aminotransferase for Huntington diseases" @default.
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