Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912098647> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2912098647 abstract "Alzheimer’s disease (AD) is the most common neurodegenerative disorder causing dementia. AD-like pathological lesions have been described in human and in several other animal species. In this study, we report AD-like pathological changes observed in the brain of a 40-year-old dolphin (Tursiups truncatus), boosting dolphins as a promising natural model of AD. The amyloid β (Aβ) was detected immunohistochemically as intraneuronal depositions, parenchymal accumulations and limited deposits in the wall of meningeal and parenchymal vessels. Also, neuronal tau positive labelling was noticed. This is the first report to show ΑpoE immunopositive reaction in dolphins. Glial fibrillary acidic protein positive astrocytes were also observed. Our findings are indicative of early AD or mild cognitive impairment pathology. So, they strongly reinforce the statement that dolphins could be a natural animal model of AD due to their lifespan, brain lesions and Αβ homology with the human peptide." @default.
- W2912098647 created "2019-02-21" @default.
- W2912098647 creator A5000603081 @default.
- W2912098647 creator A5012051748 @default.
- W2912098647 creator A5042760783 @default.
- W2912098647 creator A5045933047 @default.
- W2912098647 creator A5091467826 @default.
- W2912098647 date "2019-01-29" @default.
- W2912098647 modified "2023-10-14" @default.
- W2912098647 title "Alzheimer’s disease‐like pathological lesions in an aged bottlenose dolphin ( <i>Tursiops truncatus</i> )" @default.
- W2912098647 cites W1537685484 @default.
- W2912098647 cites W1965441890 @default.
- W2912098647 cites W1994832173 @default.
- W2912098647 cites W1995111570 @default.
- W2912098647 cites W1999657277 @default.
- W2912098647 cites W2002302477 @default.
- W2912098647 cites W2004958773 @default.
- W2912098647 cites W2005007871 @default.
- W2912098647 cites W2013554870 @default.
- W2912098647 cites W2030197947 @default.
- W2912098647 cites W2046202110 @default.
- W2912098647 cites W2046295489 @default.
- W2912098647 cites W2054439509 @default.
- W2912098647 cites W2060496326 @default.
- W2912098647 cites W2063894419 @default.
- W2912098647 cites W2069762330 @default.
- W2912098647 cites W2073038499 @default.
- W2912098647 cites W2104371090 @default.
- W2912098647 cites W2105762907 @default.
- W2912098647 cites W2108798172 @default.
- W2912098647 cites W2115676074 @default.
- W2912098647 cites W2121263729 @default.
- W2912098647 cites W2139496198 @default.
- W2912098647 cites W2148309329 @default.
- W2912098647 cites W2160033789 @default.
- W2912098647 cites W2161019904 @default.
- W2912098647 cites W2291563861 @default.
- W2912098647 cites W2304517562 @default.
- W2912098647 cites W2756783629 @default.
- W2912098647 cites W2760361302 @default.
- W2912098647 doi "https://doi.org/10.1136/vetreccr-2018-000700" @default.
- W2912098647 hasPublicationYear "2019" @default.
- W2912098647 type Work @default.
- W2912098647 sameAs 2912098647 @default.
- W2912098647 citedByCount "12" @default.
- W2912098647 countsByYear W29120986472020 @default.
- W2912098647 countsByYear W29120986472021 @default.
- W2912098647 countsByYear W29120986472022 @default.
- W2912098647 countsByYear W29120986472023 @default.
- W2912098647 crossrefType "journal-article" @default.
- W2912098647 hasAuthorship W2912098647A5000603081 @default.
- W2912098647 hasAuthorship W2912098647A5012051748 @default.
- W2912098647 hasAuthorship W2912098647A5042760783 @default.
- W2912098647 hasAuthorship W2912098647A5045933047 @default.
- W2912098647 hasAuthorship W2912098647A5091467826 @default.
- W2912098647 hasConcept C142724271 @default.
- W2912098647 hasConcept C207886595 @default.
- W2912098647 hasConcept C2776840061 @default.
- W2912098647 hasConcept C2779134260 @default.
- W2912098647 hasConcept C505870484 @default.
- W2912098647 hasConcept C71924100 @default.
- W2912098647 hasConcept C86803240 @default.
- W2912098647 hasConceptScore W2912098647C142724271 @default.
- W2912098647 hasConceptScore W2912098647C207886595 @default.
- W2912098647 hasConceptScore W2912098647C2776840061 @default.
- W2912098647 hasConceptScore W2912098647C2779134260 @default.
- W2912098647 hasConceptScore W2912098647C505870484 @default.
- W2912098647 hasConceptScore W2912098647C71924100 @default.
- W2912098647 hasConceptScore W2912098647C86803240 @default.
- W2912098647 hasIssue "1" @default.
- W2912098647 hasLocation W29120986471 @default.
- W2912098647 hasOpenAccess W2912098647 @default.
- W2912098647 hasPrimaryLocation W29120986471 @default.
- W2912098647 hasRelatedWork W2049432453 @default.
- W2912098647 hasRelatedWork W2058948935 @default.
- W2912098647 hasRelatedWork W2082482010 @default.
- W2912098647 hasRelatedWork W2120891273 @default.
- W2912098647 hasRelatedWork W2363196750 @default.
- W2912098647 hasRelatedWork W2375959005 @default.
- W2912098647 hasRelatedWork W2415099954 @default.
- W2912098647 hasRelatedWork W2465889676 @default.
- W2912098647 hasRelatedWork W3031453504 @default.
- W2912098647 hasRelatedWork W3148779192 @default.
- W2912098647 hasVolume "7" @default.
- W2912098647 isParatext "false" @default.
- W2912098647 isRetracted "false" @default.
- W2912098647 magId "2912098647" @default.
- W2912098647 workType "article" @default.