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- W2912100689 abstract "This presentation will review current and planned clinical trials of repetitive transcranial magnetic stimulation for the treatment of adolescent depression. The presenter will also review two recent discrete studies with transcranial magnetic stimulation focused on biomarker and intervention development to address suicidality in adolescents. Study 1: Utilized transcranial magnetic stimulation biomarkers to assess measures of cortical inhibition and excitability in healthy control adolescents (n=20), depressed adolescents without any history of suicidal behavior (“Depressed”, n=37), and depressed adolescents with lifetime history of suicidal behavior (“Depressed+SB”, n=17). Study 2: Examined changes in suicidal ideation with adolescents (n=19) undergoing 6 weeks of open-label, 10 Hz rTMS applied to the left dorsolateral prefrontal cortex for treatment resistant depression. Study 1: Group main effects were significant for long-interval intracortical inhibition (LICI) at interstimulus intervals (ISIs) of 100 ms and 150 ms, but not 200 ms. Depressed+SB adolescents demonstrated impaired LICI compared to healthy control and Depressed adolescents, while healthy control and depressed participants did not differ in LICI. There were positive linear relationships between lifetime suicidal behavior severity and LICI paradigm at 100-ms and 150-ms ISIs. In a post hoc receiver operating characteristic analysis, LICI significantly discriminated Depressed from Depressed+SB youth in 100-ms and 150-ms paradigms. Study 2: Suicidality as assessed by the C-SSRS improved from baseline to posttreatment (p = 0.02). Suicidality as assessed by item 13 of the CDRS-R demonstrated improvement from baseline to posttreatment (p = 0.004). These preliminary data suggest that LICI may have promise as a biomarker to assess suicidality in adolescents. Interventional, high frequency rTMS may address suicidality in adolescents. Interpretation of the present findings must be placed in the context of the limitations of an open trial of high frequency rTMS and a relatively small sample size." @default.
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- W2912100689 date "2019-03-01" @default.
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- W2912100689 title "Monitoring and modulating adolescent depression and suicidality" @default.
- W2912100689 doi "https://doi.org/10.1016/j.brs.2018.12.265" @default.
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