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- W2912102047 abstract "Management of portal vein thrombosis in cirrhotic patients does not have a consensus of publications for prevention, treatment, or monitoring, particularly in context of chronicity. In patients with esophagogastric varices who are at high risk for bleeding, decision to anticoagulate is guided by risk-benefit ratio depending on clinical scenario, where risk of bleeding is 14.4-16.2% [1]. A 60-year-old Caucasian male presented to a community hospital complaining of 2 days of epigastric and right upper quadrant abdominal pain, which had been persisting at low intensity for 1 year. Past medical history significant for cirrhosis diagnosed at age 35. Initial physical exam demonstrated vital signs within normal limits,non-distended abdomen with no appreciable fluid wave, spider angioma noted diffusely, normal bowel sounds, right upper quadrant tenderness with negative Murphy's sign, mild epigastric tenderness, no hepatosplenomegaly or asterixis, and no focal neurological deficits. CT with contrast demonstrated a contracted irregular, nodular liver consistent with cirrhosis, considerable varices, small calcified gallstones within the gallbladder without inflammation, and portal vein with extension into superior mesenteric vein thrombus with some collateral veins but not complete cavernous transformation. MELD calculated as 13 with CTP class B cirrhosis. Per endoscopy, three grade 4 varices were observed at distal third of the esophagus, and upon retroflexion, two additional grade 3 varices noted in the fundus. Overnight, patient developed worsening abdominal pain, in which repeat CT revealed progressive bowel ischemic changes and leukocytosis had increased to 34.5. On initial assessment, patient's increased variceal bleeding risk and perceived inability to survive such a bleed in the context of unclear data on the benefits of anticoagulation in portal vein thrombosis of probable chronicity, influenced decision making to not anticoagulate. However, as patient deteriorated due ischemia from the superior mesenteric vein thrombosis, patient was anticoagulated with heparin prior to transfer to a tertiary care center for possible transjugular intrahepatic portosystemic shunt intervention.Figure: Abdominal/pelvic CT scan with IV and oral contrast. (A) Transverse view demonstrating portal vein thrombosis (B) Transverse view demonstrating superior mesenteric vein thrombosis with surrounding bowel ischemia." @default.
- W2912102047 created "2019-02-21" @default.
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- W2912102047 date "2017-10-01" @default.
- W2912102047 modified "2023-10-16" @default.
- W2912102047 title "Anticoagulation of Chronic Portal Vein Thrombosis in a Patient With Esophageal Varices" @default.
- W2912102047 doi "https://doi.org/10.14309/00000434-201710001-02910" @default.
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