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- W2912103937 abstract "Abstract Acute kidney injury (AKI) remains a global challenge and, despite the availability of dialysis and transplantation, can be fatal. Those that survive an AKI are at increased risk of developing chronic kidney disease and end stage renal failure. Understanding the fundamental mechanisms underpinning the pathophysiology of AKI is critical for developing novel strategies for diagnosis and treatment. A growing body of evidence indicates that amplifying type 2 immunity may have therapeutic potential in kidney injury and disease. Of particular interest are the recently described subset of innate immune cells, termed group 2 innate lymphoid cells (ILCs). Group 2 ILCs are crucial tissue‐resident immune cells that maintain homeostasis and regulate tissue repair at multiple organ sites, including the kidney. They are critical mediators of type 2 immune responses following infection and injury. The existing literature suggests that activation of group 2 ILCs and production of a local type 2 immune milieu is protective against renal injury and associated pathology. In this review, we describe the emerging role for group 2 ILCs in renal homeostasis and repair. We provide an in‐depth discussion of the most recent literature that use preclinical models of AKI and assess the therapeutic effect of modulating group 2 ILC function. We debate the potential for targeting these cells as novel cellular therapies in AKI and discuss the implications for future studies and translation. Copyright © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd." @default.
- W2912103937 created "2019-02-21" @default.
- W2912103937 creator A5002127171 @default.
- W2912103937 creator A5010480683 @default.
- W2912103937 creator A5021376013 @default.
- W2912103937 creator A5056502030 @default.
- W2912103937 creator A5064101859 @default.
- W2912103937 creator A5076048446 @default.
- W2912103937 date "2019-03-05" @default.
- W2912103937 modified "2023-10-01" @default.
- W2912103937 title "Emerging therapeutic potential of group 2 innate lymphoid cells in acute kidney injury" @default.
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- W2912103937 doi "https://doi.org/10.1002/path.5242" @default.