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- W2912105522 abstract "Background: Less-invasive percutaneous stimulation of the auricular branch of the vagus nerve (pVNS) gained importance as a possible nonpharmacological treatment for various diseases. The objective is to perform a sensitivity analysis of a realistic numerical model of pVNS and to investigate the effects of the model parameters on the excitation threshold for single and bundled axons. Methods: Sim4Life electrostatic solver and neural tissue models were combined for electromagnetic and neural simulation. The numerical model consisted of a high-resolution model of a human ear, blood vessels, nerves, and three needle electrodes. Investigated parameters include the axon diameter and number, model temperature, ear conductivity, and electrodes’ penetration depth and position. Results: The electric field distribution was evaluated. Model temperature and ear conductivity are the non-influential parameters. Axons fiber diameter and the electrodes’ penetration depth are the most influential parameters with a maximum threshold voltage sensitivity of 32 mV for each 1 μm change in the axon diameter and 38 mV for each 0.1 mm change in the electrodes’ penetration depth. Conclusions: The established sensitivity analysis allows the identification of the influential and the non-influential parameters with a sensitivity quantification. Results suggest that the electrodes’ penetration depth is the most influential parameter." @default.
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- W2912105522 date "2019-02-06" @default.
- W2912105522 modified "2023-09-28" @default.
- W2912105522 title "Sensitivity Analysis of a Numerical Model for Percutaneous Auricular Vagus Nerve Stimulation" @default.
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- W2912105522 doi "https://doi.org/10.3390/app9030540" @default.
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