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• W2912106794 abstract "Surfactant protein D (SP-D) is considered a candidate biomarker for lung integrity and for disease progression.We determined the level of SP-D in children and adolescents with SCD and assessed its possible relation to pulmonary complications and lung function.Serum SP-D levels were assessed in 50 SCD patients compared with 30 healthy controls. High-resolution computerized tomography (HRCT) of the chest was done. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1 ), FEV1 /FVC% and forced expiratory flow rate during 25-75% of expiration (FEF25-75%) were determined.SP-D was significantly higher in SCD patients than controls, particularly patients with sickle cell anemia than those with sickle β-thalassemia. SP-D levels were significantly associated with increasing severity of interstitial lung disease. The highest SP-D levels were observed among patients with restrictive lung disease followed by mixed type then obstructive lung disease. SP-D was positively correlated to HbS and serum ferritin while negatively correlated to duration of hydroxyurea treatment and parameters of pulmonary functions. ROC curve analysis revealed that SP-D cutoff value 720 ng/mL could significantly detect the presence of abnormal pulmonary function among SCD patients with 82% sensitivity and 88% specificity. Logistic regression analysis showed that SP-D is an independent factor related to abnormal pulmonary function in SCD.SP-D may be a promising biomarker for screening of SCD patients for risk of later pulmonary complications." @default.
• W2912106794 created "2019-02-21" @default.
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• W2912106794 date "2019-01-22" @default.
• W2912106794 modified "2023-09-23" @default.
• W2912106794 title "Surfactant protein D as a marker for pulmonary complications in pediatric patients with sickle cell disease: Relation to lung function tests" @default.
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• W2912106794 doi "https://doi.org/10.1002/ppul.24257" @default.
• W2912106794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30672154" @default.
• W2912106794 hasPublicationYear "2019" @default.
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