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- W2912107157 abstract "The PLZF transcription factor is essential for osteogenic differentiation of hMSCs; however, its regulation and molecular function during this process is not fully understood. Here, we revealed that the ZBTB16 locus encoding PLZF, is repressed by Polycomb (PcG) and H3K27me3 in naive hMSCs. At the pre-osteoblast stage of differentiation, the locus lost PcG binding and H3K27me3, gained JMJD3 recruitment, and H3K27ac resulting in high expression of PLZF. Subsequently, PLZF was recruited to osteogenic enhancers, influencing H3K27 acetylation and expression of nearby genes important for osteogenic function. Furthermore, we identified a latent enhancer within the ZBTB16/PLZF locus itself that became active, gained PLZF, p300 and Mediator binding and looped to the promoter of the nicotinamide N-methyltransferase (NNMT) gene. The increased expression of NNMT correlated with a decline in SAM levels, which is dependent on PLZF and is required for osteogenic differentiation." @default.
- W2912107157 created "2019-02-21" @default.
- W2912107157 creator A5008299051 @default.
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- W2912107157 date "2019-01-23" @default.
- W2912107157 modified "2023-10-18" @default.
- W2912107157 title "PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells" @default.
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- W2912107157 doi "https://doi.org/10.7554/elife.40364" @default.
- W2912107157 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6344081" @default.
- W2912107157 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30672466" @default.
- W2912107157 hasPublicationYear "2019" @default.
- W2912107157 type Work @default.