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- W2912107318 abstract "Introduction: Current antiretroviral therapy is more effective and simpler than in previous times due to the development of new drugs with improved pharmacokinetic and pharmacodynamic profiles and the advent of single pill regimens with low toxicity that facilitate long-term adherence. The recent approval of the novel potent integrase strand-transfer inhibitor bictegravir (BIC) co-formulated with emtricitabine (FTC) and tenofovir alafenamide (TAF) in a fixed daily dose pill, B/F/TAF, adds to the list of single-tablet regimens available to treat HIV infection.Areas covered: This review provides an overview of the pharmacological and clinical information obtained from MEDLINE/PubMed publications and the latest international conferences.Expert opinion: BIC is a potent antiretroviral with an improved resistance profile over previous integrase inhibitors. Its combination with the new tenofovir prodrug TAF and FTC creates an effective regimen B/F/TAF for treatment-naïve patients and for those switching from another successful combination. B/F/TAF’s favorable pharmacokinetic profile, simple dose, low pill burden, and few drug-drug interactions or treatment-related adverse events, will make it one of the preferred regimens in the future." @default.
- W2912107318 created "2019-02-21" @default.
- W2912107318 creator A5024034549 @default.
- W2912107318 creator A5045766366 @default.
- W2912107318 date "2019-01-30" @default.
- W2912107318 modified "2023-09-26" @default.
- W2912107318 title "Bictegravir in a fixed-dose tablet with emtricitabine and tenofovir alafenamide for the treatment of HIV infection: pharmacology and clinical implications" @default.
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- W2912107318 doi "https://doi.org/10.1080/14656566.2018.1560423" @default.
- W2912107318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30698467" @default.
- W2912107318 hasPublicationYear "2019" @default.
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