FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912108564> ?p ?o ?g. }

• W2912108564 endingPage "1377" @default.
• W2912108564 startingPage "1365" @default.
• W2912108564 abstract "Tongue squamous cell carcinoma (TSCC) is the second most common malignancy in oral carcinoma. lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was regarded as an oncogenic factor in various carcinomas. However, its underlying molecular mechanisms in the development and progression of TSCC have not been well featured till now.The expressions of MALAT1, miR-140-5p and p21 (RAC1)-activated kinase 1 (PAK1) mRNA were measured by RT-qPCR assay. The protein level of PAK1 was determined by western blot analysis. Cell viability was detected by Cell Counting Kit-8 assay. Transwell chamber was used to detect cell migratory and invasive capability. Luciferase reporter assay, RNA-binding protein immunoprecipitation (RIP) assay and biotin pull-down assay were applied to evaluate the relationship between MALAT1, miR-140-5p and PAK1. Xenograft experiments were performed to assess the effect and mechanism of MALAT1 in TSCC tumor growth.The expression of MALAT1 and p21 (RAC1)-activated kinase 1 (PAK1) was upregulated and microRNA-140-5p (miR-140-5p) expression was downregulated in TSCC tissues and cells. MALAT1 knockdown induced miR-140-5p expression by direct interaction. Moreover, MALAT1 knockdown inhibited proliferation, migration, and invasion by upregulating miR-140-5p expression in TSCC cells. Additionally, PAK1 was identified as a direct target of miR-140-5p. Also, MALAT1 knockdown inhibited PAK1 expression by upregulating miR-140-5p in TSCC cells. Furthermore, miR-140-5p overexpression curbed the proliferation, migration, and invasion of TSCC cells by targeting PAK1. Finally, MALAT1 knockdown inhibited tumor growth by upregulating miR-140-5p and downregulating PAK1 in mouse xenograft models of TSCC.MALAT1 contributed to TSCC progression via miR-140-5p-PAK1 regulatory axis, highlighting a potential target for TSCC management." @default.
• W2912108564 created "2019-02-21" @default.
• W2912108564 creator A5003738589 @default.
• W2912108564 creator A5016407094 @default.
• W2912108564 creator A5047308968 @default.
• W2912108564 creator A5066221170 @default.
• W2912108564 creator A5086355031 @default.
• W2912108564 date "2019-02-01" @default.
• W2912108564 modified "2023-10-16" @default.
• W2912108564 title "<p>lncRNA <em>MALAT1</em> potentiates the progression of tongue squamous cell carcinoma through regulating <em>miR-140-5p</em>-PAK1 pathway</p>" @default.
• W2912108564 cites W104317965 @default.
• W2912108564 cites W1629166275 @default.
• W2912108564 cites W1949987295 @default.
• W2912108564 cites W1973182416 @default.
• W2912108564 cites W1975068616 @default.
• W2912108564 cites W1989057528 @default.
• W2912108564 cites W2029483334 @default.
• W2912108564 cites W2037703878 @default.
• W2912108564 cites W2068728873 @default.
• W2912108564 cites W2077879660 @default.
• W2912108564 cites W2128619556 @default.
• W2912108564 cites W2156026719 @default.
• W2912108564 cites W2175326782 @default.
• W2912108564 cites W2272984102 @default.
• W2912108564 cites W2283522739 @default.
• W2912108564 cites W2403021866 @default.
• W2912108564 cites W2461477959 @default.
• W2912108564 cites W2510626203 @default.
• W2912108564 cites W2516968514 @default.
• W2912108564 cites W2548573138 @default.
• W2912108564 cites W2559912257 @default.
• W2912108564 cites W2568525761 @default.
• W2912108564 cites W2588862121 @default.
• W2912108564 cites W2590017937 @default.
• W2912108564 cites W2605180138 @default.
• W2912108564 cites W2613828098 @default.
• W2912108564 cites W2623016688 @default.
• W2912108564 cites W2625600561 @default.
• W2912108564 cites W2735799965 @default.
• W2912108564 cites W2736691269 @default.
• W2912108564 cites W2746324226 @default.
• W2912108564 cites W2754562046 @default.
• W2912108564 cites W2756542602 @default.
• W2912108564 cites W2781525129 @default.
• W2912108564 cites W2782718131 @default.
• W2912108564 cites W2783763393 @default.
• W2912108564 cites W2800620450 @default.
• W2912108564 cites W2809797501 @default.
• W2912108564 cites W2885057343 @default.
• W2912108564 cites W3008504451 @default.
• W2912108564 cites W777870249 @default.
• W2912108564 doi "https://doi.org/10.2147/ott.s192069" @default.
• W2912108564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6388959" @default.
• W2912108564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30863103" @default.
• W2912108564 hasPublicationYear "2019" @default.
• W2912108564 type Work @default.
• W2912108564 sameAs 2912108564 @default.
• W2912108564 citedByCount "32" @default.
• W2912108564 countsByYear W29121085642019 @default.
• W2912108564 countsByYear W29121085642020 @default.
• W2912108564 countsByYear W29121085642021 @default.
• W2912108564 countsByYear W29121085642022 @default.
• W2912108564 countsByYear W29121085642023 @default.
• W2912108564 crossrefType "journal-article" @default.
• W2912108564 hasAuthorship W2912108564A5003738589 @default.
• W2912108564 hasAuthorship W2912108564A5016407094 @default.
• W2912108564 hasAuthorship W2912108564A5047308968 @default.
• W2912108564 hasAuthorship W2912108564A5066221170 @default.
• W2912108564 hasAuthorship W2912108564A5086355031 @default.
• W2912108564 hasBestOaLocation W29121085641 @default.
• W2912108564 hasConcept C104317684 @default.
• W2912108564 hasConcept C127561419 @default.
• W2912108564 hasConcept C145059251 @default.
• W2912108564 hasConcept C153911025 @default.
• W2912108564 hasConcept C173396325 @default.
• W2912108564 hasConcept C185592680 @default.
• W2912108564 hasConcept C190283241 @default.
• W2912108564 hasConcept C2779134362 @default.
• W2912108564 hasConcept C2779717556 @default.
• W2912108564 hasConcept C502942594 @default.
• W2912108564 hasConcept C55493867 @default.
• W2912108564 hasConcept C62112901 @default.
• W2912108564 hasConcept C62203573 @default.
• W2912108564 hasConcept C62478195 @default.
• W2912108564 hasConcept C86803240 @default.
• W2912108564 hasConcept C95444343 @default.
• W2912108564 hasConceptScore W2912108564C104317684 @default.
• W2912108564 hasConceptScore W2912108564C127561419 @default.
• W2912108564 hasConceptScore W2912108564C145059251 @default.
• W2912108564 hasConceptScore W2912108564C153911025 @default.
• W2912108564 hasConceptScore W2912108564C173396325 @default.
• W2912108564 hasConceptScore W2912108564C185592680 @default.
• W2912108564 hasConceptScore W2912108564C190283241 @default.
• W2912108564 hasConceptScore W2912108564C2779134362 @default.
• W2912108564 hasConceptScore W2912108564C2779717556 @default.
• W2912108564 hasConceptScore W2912108564C502942594 @default.
• W2912108564 hasConceptScore W2912108564C55493867 @default.
• W2912108564 hasConceptScore W2912108564C62112901 @default.

• next