Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912109461> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2912109461 abstract "Sulforaphane reduces brain injury following experimental vascular cognitive impairment by activating Nrf2 pathway Aims: Vascular cognitive impairment (VCI) is a type of dementia, and its major pathophysiological process is chronic ischemia, leading to the blood-brain barrier (BBB) disintegration, neuronal death, and white matter injury. The aim of current study is to test whether sulforaphane (Sfn), a natural activator of nuclear factor erythroid 2-related factor 2 (Nrf2), protects the brain against chronic ischemic injury and improve cognitive function after experiment VCI. Results: VCI was induced in rats by permanent occlusion of both common carotid arteries, which caused remarkable cognitive impairment, accompanied by neuronal death in the cortex and hippocampal CA1, demyelination in the corpus callosum and hippocampal fimbria, and accumulation of myelin debris in the corpus callosum. Sfn alleviated the cognitive impairment and reduced these accompanying pathophysiological changes. Sfn neuroprotection was associated with enhanced Nrf2 activation. In vitro, Sfn reduced neuronal and endothelial death, maintained the integrity of the BBB after oxygen-glucose deprivation; and Nrf2 knockdown with shRNA significantly reduced the protection of Sfn. Furthermore, Nrf2 knockdown in endothelial cells decreased the level of claudin-5, a tight junction protein; and luciferase assay suggested that claudin-5 might be a downstream target of Nrf2. Innovation: This is the first study demonstrates the neuroprotective effects of Sfn against neuronal loss, white matter injury, and BBB damage after VCI. Furthermore, it discovers the accumulated myelin debris in WM and that Nrf2 may control the expression of claudin-5. Conclusion: Our results suggest that Sfn provides comprehensive protection to the brain and may be a promising agent targeting cognitive impairment." @default.
- W2912109461 created "2019-02-21" @default.
- W2912109461 creator A5004341581 @default.
- W2912109461 creator A5012582852 @default.
- W2912109461 creator A5014032225 @default.
- W2912109461 creator A5052274720 @default.
- W2912109461 creator A5068992032 @default.
- W2912109461 date "2019-02-01" @default.
- W2912109461 modified "2023-09-27" @default.
- W2912109461 title "Abstract TP559: Sulforaphane Confers Neuroprotection Against Neuronal Loss, White Matter Injury and BBB Damage Following Experimental Vascular Cognitive Impairment" @default.
- W2912109461 doi "https://doi.org/10.1161/str.50.suppl_1.tp559" @default.
- W2912109461 hasPublicationYear "2019" @default.
- W2912109461 type Work @default.
- W2912109461 sameAs 2912109461 @default.
- W2912109461 citedByCount "0" @default.
- W2912109461 crossrefType "journal-article" @default.
- W2912109461 hasAuthorship W2912109461A5004341581 @default.
- W2912109461 hasAuthorship W2912109461A5012582852 @default.
- W2912109461 hasAuthorship W2912109461A5014032225 @default.
- W2912109461 hasAuthorship W2912109461A5052274720 @default.
- W2912109461 hasAuthorship W2912109461A5068992032 @default.
- W2912109461 hasConcept C126322002 @default.
- W2912109461 hasConcept C126838900 @default.
- W2912109461 hasConcept C142724271 @default.
- W2912109461 hasConcept C143409427 @default.
- W2912109461 hasConcept C148762608 @default.
- W2912109461 hasConcept C169760540 @default.
- W2912109461 hasConcept C25498285 @default.
- W2912109461 hasConcept C2778183499 @default.
- W2912109461 hasConcept C2780841255 @default.
- W2912109461 hasConcept C2781192897 @default.
- W2912109461 hasConcept C502942594 @default.
- W2912109461 hasConcept C71924100 @default.
- W2912109461 hasConcept C86803240 @default.
- W2912109461 hasConcept C98274493 @default.
- W2912109461 hasConceptScore W2912109461C126322002 @default.
- W2912109461 hasConceptScore W2912109461C126838900 @default.
- W2912109461 hasConceptScore W2912109461C142724271 @default.
- W2912109461 hasConceptScore W2912109461C143409427 @default.
- W2912109461 hasConceptScore W2912109461C148762608 @default.
- W2912109461 hasConceptScore W2912109461C169760540 @default.
- W2912109461 hasConceptScore W2912109461C25498285 @default.
- W2912109461 hasConceptScore W2912109461C2778183499 @default.
- W2912109461 hasConceptScore W2912109461C2780841255 @default.
- W2912109461 hasConceptScore W2912109461C2781192897 @default.
- W2912109461 hasConceptScore W2912109461C502942594 @default.
- W2912109461 hasConceptScore W2912109461C71924100 @default.
- W2912109461 hasConceptScore W2912109461C86803240 @default.
- W2912109461 hasConceptScore W2912109461C98274493 @default.
- W2912109461 hasIssue "Suppl_1" @default.
- W2912109461 hasLocation W29121094611 @default.
- W2912109461 hasOpenAccess W2912109461 @default.
- W2912109461 hasPrimaryLocation W29121094611 @default.
- W2912109461 hasRelatedWork W1971355501 @default.
- W2912109461 hasRelatedWork W1990981916 @default.
- W2912109461 hasRelatedWork W2076571486 @default.
- W2912109461 hasRelatedWork W2133783484 @default.
- W2912109461 hasRelatedWork W2483278632 @default.
- W2912109461 hasRelatedWork W2536083918 @default.
- W2912109461 hasRelatedWork W2912109461 @default.
- W2912109461 hasRelatedWork W3215729057 @default.
- W2912109461 hasRelatedWork W4250501032 @default.
- W2912109461 hasRelatedWork W4283793070 @default.
- W2912109461 hasVolume "50" @default.
- W2912109461 isParatext "false" @default.
- W2912109461 isRetracted "false" @default.
- W2912109461 magId "2912109461" @default.
- W2912109461 workType "article" @default.