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- W2912110678 abstract "The overall and expanding usefulness of positron emission tomography (PET) as an imaging modality is dependent upon the number and variety of radiotracers that can be synthesized and subsequently used to investigate human physiology and disease. Carbon-11 is produced from a cyclotron in the form of 11CO2 or 11CH4 in sufficient quantity and with high specific activity for PET imaging. The development of a one-pot method to directly incorporate 11CO2 into a carbamate moiety has simplified the synthetic process for many biological molecules. All radiochemical syntheses must be carried out using appropriate equipment in a facility authorized for the use of radioactive materials. Trained personnel must carry out quality control (QC) procedures, and each dose must meet all established QC criteria before release to the clinic. Some of the procedures discussed in the chapter are determination of radiochemical yield, radiochemical identity and purity." @default.
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- W2912110678 date "2015-05-08" @default.
- W2912110678 modified "2023-09-23" @default.
- W2912110678 title "One-Pot, Direct Incorporation of [11CO2]into Carbamates" @default.
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- W2912110678 doi "https://doi.org/10.1002/9781118834114.ch19" @default.
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