Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912111006> ?p ?o ?g. }
- W2912111006 abstract "Optogenetics and chemogenetics are powerful tools, allowing the specific activation or inhibition of targeted neuronal subpopulations. Application of these techniques to sleep and circadian research has resulted in the unveiling of several neuronal populations that are involved in sleep-wake control, and allowed a comprehensive interrogation of the circuitry through which these nodes are coordinated to orchestrate the sleep-wake cycle. In this review, we discuss six recently described sleep-wake and circadian circuits that show promise as therapeutic targets for sleep medicine. The parafacial zone (PZ) and the ventral tegmental area (VTA) are potential druggable targets for the treatment of insomnia. The brainstem circuit underlying rapid eye movement sleep behavior disorder (RBD) offers new possibilities for treating RBD and neurodegenerative synucleinopathies, whereas the parabrachial nucleus, as a nexus linking arousal state control and breathing, is a promising target for developing treatments for sleep apnea. Therapies that act upon the hypothalamic circuitry underlying the circadian regulation of aggression or the photic regulation of arousal and mood pathway carry enormous potential for helping to reduce the socioeconomic burden of neuropsychiatric and neurodegenerative disorders on society. Intriguingly, the development of chemogenetics as a therapeutic strategy is now well underway and such an approach has the capacity to lead to more focused and less invasive therapies for treating sleep-wake disorders and related comorbidities." @default.
- W2912111006 created "2019-02-21" @default.
- W2912111006 creator A5000567670 @default.
- W2912111006 creator A5022523399 @default.
- W2912111006 creator A5033452909 @default.
- W2912111006 creator A5055393465 @default.
- W2912111006 creator A5056513634 @default.
- W2912111006 creator A5084984204 @default.
- W2912111006 creator A5089324947 @default.
- W2912111006 date "2019-02-02" @default.
- W2912111006 modified "2023-10-15" @default.
- W2912111006 title "Newly identified sleep–wake and circadian circuits as potential therapeutic targets" @default.
- W2912111006 cites W1053287285 @default.
- W2912111006 cites W1139015881 @default.
- W2912111006 cites W1488974332 @default.
- W2912111006 cites W1520340241 @default.
- W2912111006 cites W1538619854 @default.
- W2912111006 cites W1560106330 @default.
- W2912111006 cites W1578925495 @default.
- W2912111006 cites W1588053646 @default.
- W2912111006 cites W1616842389 @default.
- W2912111006 cites W1627229807 @default.
- W2912111006 cites W1732462733 @default.
- W2912111006 cites W180785715 @default.
- W2912111006 cites W1899857231 @default.
- W2912111006 cites W1940376800 @default.
- W2912111006 cites W1947202934 @default.
- W2912111006 cites W1963772961 @default.
- W2912111006 cites W1965095016 @default.
- W2912111006 cites W1966403223 @default.
- W2912111006 cites W1967191643 @default.
- W2912111006 cites W1967534613 @default.
- W2912111006 cites W1967947158 @default.
- W2912111006 cites W1968173634 @default.
- W2912111006 cites W1970130379 @default.
- W2912111006 cites W1973729800 @default.
- W2912111006 cites W1974178053 @default.
- W2912111006 cites W1975146102 @default.
- W2912111006 cites W1977267085 @default.
- W2912111006 cites W1977957829 @default.
- W2912111006 cites W1978920053 @default.
- W2912111006 cites W1979803052 @default.
- W2912111006 cites W1981775108 @default.
- W2912111006 cites W1983935664 @default.
- W2912111006 cites W1984332125 @default.
- W2912111006 cites W1984796397 @default.
- W2912111006 cites W1986608768 @default.
- W2912111006 cites W1987514581 @default.
- W2912111006 cites W1987785323 @default.
- W2912111006 cites W1993134393 @default.
- W2912111006 cites W1993608941 @default.
- W2912111006 cites W1995200202 @default.
- W2912111006 cites W1995973145 @default.
- W2912111006 cites W1999309925 @default.
- W2912111006 cites W2002867180 @default.
- W2912111006 cites W2006862529 @default.
- W2912111006 cites W2007140413 @default.
- W2912111006 cites W2007311340 @default.
- W2912111006 cites W2007569082 @default.
- W2912111006 cites W2009293658 @default.
- W2912111006 cites W2010055704 @default.
- W2912111006 cites W2011374445 @default.
- W2912111006 cites W2011403532 @default.
- W2912111006 cites W2011454209 @default.
- W2912111006 cites W2011580879 @default.
- W2912111006 cites W2017625070 @default.
- W2912111006 cites W2018669712 @default.
- W2912111006 cites W2020551007 @default.
- W2912111006 cites W2021216897 @default.
- W2912111006 cites W2022436936 @default.
- W2912111006 cites W2022561563 @default.
- W2912111006 cites W2024091035 @default.
- W2912111006 cites W2024680557 @default.
- W2912111006 cites W2027429673 @default.
- W2912111006 cites W2027613548 @default.
- W2912111006 cites W2028980996 @default.
- W2912111006 cites W2035516697 @default.
- W2912111006 cites W2035853180 @default.
- W2912111006 cites W2037495834 @default.
- W2912111006 cites W2037518902 @default.
- W2912111006 cites W2038035975 @default.
- W2912111006 cites W2040991910 @default.
- W2912111006 cites W2042060172 @default.
- W2912111006 cites W2042904658 @default.
- W2912111006 cites W2043537645 @default.
- W2912111006 cites W2046060806 @default.
- W2912111006 cites W2047735953 @default.
- W2912111006 cites W2048534764 @default.
- W2912111006 cites W2052877278 @default.
- W2912111006 cites W2054281595 @default.
- W2912111006 cites W2059600252 @default.
- W2912111006 cites W2060916551 @default.
- W2912111006 cites W2062109199 @default.
- W2912111006 cites W2063210874 @default.
- W2912111006 cites W2064376850 @default.
- W2912111006 cites W2066183013 @default.
- W2912111006 cites W2066674357 @default.
- W2912111006 cites W2069566150 @default.
- W2912111006 cites W2071898411 @default.
- W2912111006 cites W2072154498 @default.