FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912111325> ?p ?o ?g. }

• W2912111325 endingPage "70" @default.
• W2912111325 startingPage "59" @default.
• W2912111325 abstract "Clinical utility of lornoxicam in oral therapy is primarily restricted by the low solubility and gastric adverse effects. This study evaluated the prospective of optimized proniosomal gel to improve the clinical efficacy of lornoxicam and compare with oral therapy. Proniosomes were formulated by coacervation phase separation technique using span 60, lecithin and cholesterol. A four-factor three-level Box-Behnken design was used to evaluate the effect of amount of four independent variables; span 60 (X1), cholesterol (X2), lecithin (X3) and lornoxicam (X4) on response variables; vesicle size (Y1), entrapment efficiency (Y2) and transdermal flux (Y3). The selected proniosomal gel (F19) was characterized, and evaluated for the transdermal efficacy by ex vivo and in vivo experiments. Optimization study signifies that amount of formulation components (span 60, cholesterol, lecithin and lornoxicam) influence the vesicle size, entrapment efficiency and/or transdermal flux. Optimized formulation F19 exhibited nano size with high entrapment efficiency, adequate zeta potential, greater transdermal flux and better stability (at refrigerated conditions). The entrapment of lornoxicam in the bilayers of proniosome vesicles was confirmed by differential scanning calorimeter. Release profile of F19 was distinct (p < 0.001) from gel prepared using hydroxypropyl methylcellulose (control) and displayed steady lornoxicam release by Fickian diffusion. Transdermal administration of F19 significantly inhibited the carrageenan induced hind-paw edema in rats as compared to oral lornoxicam group. The data observed in this study demonstrated that the developed proniosomal gel (F19) improved the clinical efficacy of lornoxicam as compared to oral therapy." @default.
• W2912111325 created "2019-02-21" @default.
• W2912111325 creator A5001934184 @default.
• W2912111325 creator A5003256942 @default.
• W2912111325 creator A5014070053 @default.
• W2912111325 creator A5055789136 @default.
• W2912111325 creator A5059202448 @default.
• W2912111325 date "2019-01-30" @default.
• W2912111325 modified "2023-10-17" @default.
• W2912111325 title "Proniosomal gel for transdermal delivery of lornoxicam: optimization using factorial design and in vivo evaluation in rats" @default.
• W2912111325 cites W190247906 @default.
• W2912111325 cites W1972723441 @default.
• W2912111325 cites W1974637913 @default.
• W2912111325 cites W1979209041 @default.
• W2912111325 cites W1982128828 @default.
• W2912111325 cites W1990281963 @default.
• W2912111325 cites W1994381824 @default.
• W2912111325 cites W2001964160 @default.
• W2912111325 cites W2003587134 @default.
• W2912111325 cites W2007190277 @default.
• W2912111325 cites W2033362260 @default.
• W2912111325 cites W2039551585 @default.
• W2912111325 cites W2045113343 @default.
• W2912111325 cites W2061802024 @default.
• W2912111325 cites W2066432116 @default.
• W2912111325 cites W2071703022 @default.
• W2912111325 cites W2075706054 @default.
• W2912111325 cites W2082724339 @default.
• W2912111325 cites W2085205359 @default.
• W2912111325 cites W2103830394 @default.
• W2912111325 cites W2107395352 @default.
• W2912111325 cites W2111386863 @default.
• W2912111325 cites W2115439624 @default.
• W2912111325 cites W2118322952 @default.
• W2912111325 cites W2118384832 @default.
• W2912111325 cites W2133566692 @default.
• W2912111325 cites W2161530911 @default.
• W2912111325 cites W2260076207 @default.
• W2912111325 cites W2283430224 @default.
• W2912111325 cites W2322244831 @default.
• W2912111325 cites W2324048625 @default.
• W2912111325 cites W2417346207 @default.
• W2912111325 cites W2518616976 @default.
• W2912111325 cites W2594374499 @default.
• W2912111325 cites W2769745398 @default.
• W2912111325 cites W2775567338 @default.
• W2912111325 cites W2777881230 @default.
• W2912111325 cites W2896249550 @default.
• W2912111325 doi "https://doi.org/10.1007/s40199-019-00242-x" @default.
• W2912111325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6593013" @default.
• W2912111325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30701460" @default.
• W2912111325 hasPublicationYear "2019" @default.
• W2912111325 type Work @default.
• W2912111325 sameAs 2912111325 @default.
• W2912111325 citedByCount "40" @default.
• W2912111325 countsByYear W29121113252019 @default.
• W2912111325 countsByYear W29121113252020 @default.
• W2912111325 countsByYear W29121113252021 @default.
• W2912111325 countsByYear W29121113252022 @default.
• W2912111325 countsByYear W29121113252023 @default.
• W2912111325 crossrefType "journal-article" @default.
• W2912111325 hasAuthorship W2912111325A5001934184 @default.
• W2912111325 hasAuthorship W2912111325A5003256942 @default.
• W2912111325 hasAuthorship W2912111325A5014070053 @default.
• W2912111325 hasAuthorship W2912111325A5055789136 @default.
• W2912111325 hasAuthorship W2912111325A5059202448 @default.
• W2912111325 hasBestOaLocation W29121113252 @default.
• W2912111325 hasConcept C105795698 @default.
• W2912111325 hasConcept C130316041 @default.
• W2912111325 hasConcept C150903083 @default.
• W2912111325 hasConcept C169222746 @default.
• W2912111325 hasConcept C185154212 @default.
• W2912111325 hasConcept C185592680 @default.
• W2912111325 hasConcept C192562407 @default.
• W2912111325 hasConcept C205679159 @default.
• W2912111325 hasConcept C207001950 @default.
• W2912111325 hasConcept C2779040406 @default.
• W2912111325 hasConcept C2779564620 @default.
• W2912111325 hasConcept C2780820201 @default.
• W2912111325 hasConcept C33923547 @default.
• W2912111325 hasConcept C41625074 @default.
• W2912111325 hasConcept C43617362 @default.
• W2912111325 hasConcept C55493867 @default.
• W2912111325 hasConcept C71924100 @default.
• W2912111325 hasConcept C72918618 @default.
• W2912111325 hasConcept C86803240 @default.
• W2912111325 hasConcept C98274493 @default.
• W2912111325 hasConceptScore W2912111325C105795698 @default.
• W2912111325 hasConceptScore W2912111325C130316041 @default.
• W2912111325 hasConceptScore W2912111325C150903083 @default.
• W2912111325 hasConceptScore W2912111325C169222746 @default.
• W2912111325 hasConceptScore W2912111325C185154212 @default.
• W2912111325 hasConceptScore W2912111325C185592680 @default.
• W2912111325 hasConceptScore W2912111325C192562407 @default.
• W2912111325 hasConceptScore W2912111325C205679159 @default.
• W2912111325 hasConceptScore W2912111325C207001950 @default.
• W2912111325 hasConceptScore W2912111325C2779040406 @default.
• W2912111325 hasConceptScore W2912111325C2779564620 @default.

• next