FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912114287> ?p ?o ?g. }

• W2912114287 abstract "Epidemiological evidence finds cigarette smoking is a common risk factor for a number of diseases, not only in the lung but also in other tissues such as the gastrointestinal tract. While it is well documented that smoking directly drives lung inflammatory disease, how it promotes disease in peripheral tissues is incompletely understood. In this study, we utilized a mouse model of short-term smoke exposure and found increased Th17 cells and neutrophilia in the lung as well as in the circulation. Following intestinal inflammatory challenge, smoke exposed mice showed increased pathology which corresponds to enhanced intestinal Th17 cells, ILC3 and neutrophils within intestinal tissue. Using cellular depletion and genetic deficiencies, we define a cellular loop by which IL-17A and downstream neutrophils drive cigarette smoke-enhanced intestinal inflammation. Collectively, cigarette smoke induced local lung Th17 responses lead to increased systemic susceptibility to inflammatory insult through enhanced circulating neutrophils. These data demonstrate a cellular pathway by which inflammatory challenge in the lung can sensitize the intestine to enhanced pathological innate and adaptive immune responses." @default.
• W2912114287 created "2019-02-21" @default.
• W2912114287 creator A5011081844 @default.
• W2912114287 creator A5016586314 @default.
• W2912114287 creator A5016767139 @default.
• W2912114287 creator A5034841356 @default.
• W2912114287 creator A5044773596 @default.
• W2912114287 creator A5047708097 @default.
• W2912114287 creator A5067889643 @default.
• W2912114287 creator A5077013841 @default.
• W2912114287 creator A5080968268 @default.
• W2912114287 creator A5091466042 @default.
• W2912114287 date "2019-01-29" @default.
• W2912114287 modified "2023-10-16" @default.
• W2912114287 title "Cigarette Smoke Induces Intestinal Inflammation via a Th17 Cell-Neutrophil Axis" @default.
• W2912114287 cites W1925726049 @default.
• W2912114287 cites W1967270772 @default.
• W2912114287 cites W1970824175 @default.
• W2912114287 cites W1993148904 @default.
• W2912114287 cites W1997498829 @default.
• W2912114287 cites W2001938165 @default.
• W2912114287 cites W2017364473 @default.
• W2912114287 cites W2018075167 @default.
• W2912114287 cites W2024346860 @default.
• W2912114287 cites W2034757334 @default.
• W2912114287 cites W2048469790 @default.
• W2912114287 cites W2089830686 @default.
• W2912114287 cites W2093785176 @default.
• W2912114287 cites W2103747137 @default.
• W2912114287 cites W2108782014 @default.
• W2912114287 cites W2116515517 @default.
• W2912114287 cites W2118278569 @default.
• W2912114287 cites W2122278678 @default.
• W2912114287 cites W2126321027 @default.
• W2912114287 cites W2144898082 @default.
• W2912114287 cites W2145520421 @default.
• W2912114287 cites W2163582403 @default.
• W2912114287 cites W2164386968 @default.
• W2912114287 cites W2168877831 @default.
• W2912114287 cites W2528396364 @default.
• W2912114287 cites W2616875005 @default.
• W2912114287 cites W2763151664 @default.
• W2912114287 cites W2765759949 @default.
• W2912114287 cites W2766410684 @default.
• W2912114287 cites W2811023043 @default.
• W2912114287 doi "https://doi.org/10.3389/fimmu.2019.00075" @default.
• W2912114287 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6361762" @default.
• W2912114287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30761142" @default.
• W2912114287 hasPublicationYear "2019" @default.
• W2912114287 type Work @default.
• W2912114287 sameAs 2912114287 @default.
• W2912114287 citedByCount "28" @default.
• W2912114287 countsByYear W29121142872020 @default.
• W2912114287 countsByYear W29121142872021 @default.
• W2912114287 countsByYear W29121142872022 @default.
• W2912114287 countsByYear W29121142872023 @default.
• W2912114287 crossrefType "journal-article" @default.
• W2912114287 hasAuthorship W2912114287A5011081844 @default.
• W2912114287 hasAuthorship W2912114287A5016586314 @default.
• W2912114287 hasAuthorship W2912114287A5016767139 @default.
• W2912114287 hasAuthorship W2912114287A5034841356 @default.
• W2912114287 hasAuthorship W2912114287A5044773596 @default.
• W2912114287 hasAuthorship W2912114287A5047708097 @default.
• W2912114287 hasAuthorship W2912114287A5067889643 @default.
• W2912114287 hasAuthorship W2912114287A5077013841 @default.
• W2912114287 hasAuthorship W2912114287A5080968268 @default.
• W2912114287 hasAuthorship W2912114287A5091466042 @default.
• W2912114287 hasBestOaLocation W29121142871 @default.
• W2912114287 hasConcept C126322002 @default.
• W2912114287 hasConcept C136449434 @default.
• W2912114287 hasConcept C203014093 @default.
• W2912114287 hasConcept C2776914184 @default.
• W2912114287 hasConcept C2777714996 @default.
• W2912114287 hasConcept C2777802486 @default.
• W2912114287 hasConcept C2780512811 @default.
• W2912114287 hasConcept C71924100 @default.
• W2912114287 hasConcept C8891405 @default.
• W2912114287 hasConceptScore W2912114287C126322002 @default.
• W2912114287 hasConceptScore W2912114287C136449434 @default.
• W2912114287 hasConceptScore W2912114287C203014093 @default.
• W2912114287 hasConceptScore W2912114287C2776914184 @default.
• W2912114287 hasConceptScore W2912114287C2777714996 @default.
• W2912114287 hasConceptScore W2912114287C2777802486 @default.
• W2912114287 hasConceptScore W2912114287C2780512811 @default.
• W2912114287 hasConceptScore W2912114287C71924100 @default.
• W2912114287 hasConceptScore W2912114287C8891405 @default.
• W2912114287 hasLocation W29121142871 @default.
• W2912114287 hasLocation W29121142872 @default.
• W2912114287 hasLocation W29121142873 @default.
• W2912114287 hasLocation W29121142874 @default.
• W2912114287 hasOpenAccess W2912114287 @default.
• W2912114287 hasPrimaryLocation W29121142871 @default.
• W2912114287 hasRelatedWork W1528000696 @default.
• W2912114287 hasRelatedWork W1966043026 @default.
• W2912114287 hasRelatedWork W1986311588 @default.
• W2912114287 hasRelatedWork W2025155642 @default.
• W2912114287 hasRelatedWork W2027848803 @default.
• W2912114287 hasRelatedWork W2029568741 @default.
• W2912114287 hasRelatedWork W2399676964 @default.
• W2912114287 hasRelatedWork W2794887651 @default.

• next