FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912115454> ?p ?o ?g. }

• W2912115454 endingPage "166" @default.
• W2912115454 startingPage "166" @default.
• W2912115454 abstract "Slit2 expression is downregulated in various cancers, including lung cancer. We identified two Slit2 splicing variants at exon15—Slit2-WT and Slit2-ΔE15. In the RT-PCR analyses, the Slit2-WT isoform was predominantly expressed in all the lung cancer specimens and in their normal lung counterparts, whereas Slit2-ΔE15 was equivalently or predominantly expressed in 41% of the pneumothorax specimens. A kRasG12D transgenic mice system was used to study the effects of tumorigenesis on the expressions of the Slit2-exon15 isoforms. The results revealed that a kRasG12D-induced lung tumor increased the Slit2-WT/Slit2-ΔE15 ratio and total Slit2 expression level. However, the lung tumors generated via a tail vein injection of lung cancer cells decreased the Slit2-WT/Slit2-ΔE15 ratio and total Slit2 expression level. Interestingly, the lipopolysaccharide (LPS)-induced lung inflammation also decreased the Slit2-WT/Slit2-ΔE15 ratio. Since Slit2 functions as an anti-inflammatory factor, the expression of Slit2 increases in kRasG12D lungs, which indicates that Slit2 suppresses immunity during tumorigenesis. However, an injection of lung cancer cells via the tail vein and the LPS-induced lung inflammation both decreased the Slit2 expression. The increased Slit2 in the tumor microenvironment was mostly Slit2-WT, which lacks growth inhibitory activity. Thus, the results of our study suggested that the upregulation of Slit2-WT, but not Slit2-ΔE15, in a cancer microenvironment is an important factor in suppressing immunity while not interfering with cancer growth." @default.
• W2912115454 created "2019-02-21" @default.
• W2912115454 creator A5005860138 @default.
• W2912115454 creator A5040552201 @default.
• W2912115454 creator A5042818728 @default.
• W2912115454 creator A5055200587 @default.
• W2912115454 creator A5062103392 @default.
• W2912115454 creator A5075418260 @default.
• W2912115454 creator A5075523270 @default.
• W2912115454 creator A5088878540 @default.
• W2912115454 date "2019-02-01" @default.
• W2912115454 modified "2023-10-16" @default.
• W2912115454 title "Lung Tumorigenesis Alters the Expression of Slit2-exon15 Splicing Variants in Tumor Microenvironment" @default.
• W2912115454 cites W1561902389 @default.
• W2912115454 cites W1868441928 @default.
• W2912115454 cites W1876256408 @default.
• W2912115454 cites W1919452523 @default.
• W2912115454 cites W1941914875 @default.
• W2912115454 cites W1955158742 @default.
• W2912115454 cites W1956372587 @default.
• W2912115454 cites W1966385034 @default.
• W2912115454 cites W1967450020 @default.
• W2912115454 cites W1969884079 @default.
• W2912115454 cites W1972817334 @default.
• W2912115454 cites W1977937744 @default.
• W2912115454 cites W1978493501 @default.
• W2912115454 cites W1979522747 @default.
• W2912115454 cites W1980136245 @default.
• W2912115454 cites W1988238602 @default.
• W2912115454 cites W1998282976 @default.
• W2912115454 cites W2008790756 @default.
• W2912115454 cites W2009743745 @default.
• W2912115454 cites W2018216286 @default.
• W2912115454 cites W2019129382 @default.
• W2912115454 cites W2025199643 @default.
• W2912115454 cites W2031005356 @default.
• W2912115454 cites W2056220715 @default.
• W2912115454 cites W2088023695 @default.
• W2912115454 cites W2089553333 @default.
• W2912115454 cites W2106340568 @default.
• W2912115454 cites W2107508493 @default.
• W2912115454 cites W2109433253 @default.
• W2912115454 cites W2126113793 @default.
• W2912115454 cites W2146115802 @default.
• W2912115454 cites W2159956893 @default.
• W2912115454 cites W2193253393 @default.
• W2912115454 cites W2265199210 @default.
• W2912115454 cites W2585879868 @default.
• W2912115454 cites W2590740193 @default.
• W2912115454 cites W2604839219 @default.
• W2912115454 cites W2789699341 @default.
• W2912115454 doi "https://doi.org/10.3390/cancers11020166" @default.
• W2912115454 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6406468" @default.
• W2912115454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30717252" @default.
• W2912115454 hasPublicationYear "2019" @default.
• W2912115454 type Work @default.
• W2912115454 sameAs 2912115454 @default.
• W2912115454 citedByCount "2" @default.
• W2912115454 countsByYear W29121154542020 @default.
• W2912115454 crossrefType "journal-article" @default.
• W2912115454 hasAuthorship W2912115454A5005860138 @default.
• W2912115454 hasAuthorship W2912115454A5040552201 @default.
• W2912115454 hasAuthorship W2912115454A5042818728 @default.
• W2912115454 hasAuthorship W2912115454A5055200587 @default.
• W2912115454 hasAuthorship W2912115454A5062103392 @default.
• W2912115454 hasAuthorship W2912115454A5075418260 @default.
• W2912115454 hasAuthorship W2912115454A5075523270 @default.
• W2912115454 hasAuthorship W2912115454A5088878540 @default.
• W2912115454 hasBestOaLocation W29121154541 @default.
• W2912115454 hasConcept C121608353 @default.
• W2912115454 hasConcept C126322002 @default.
• W2912115454 hasConcept C142724271 @default.
• W2912115454 hasConcept C173396325 @default.
• W2912115454 hasConcept C203014093 @default.
• W2912115454 hasConcept C2776107976 @default.
• W2912115454 hasConcept C2776256026 @default.
• W2912115454 hasConcept C2776914184 @default.
• W2912115454 hasConcept C2777714996 @default.
• W2912115454 hasConcept C3020616263 @default.
• W2912115454 hasConcept C502942594 @default.
• W2912115454 hasConcept C54355233 @default.
• W2912115454 hasConcept C555283112 @default.
• W2912115454 hasConcept C71924100 @default.
• W2912115454 hasConcept C81885089 @default.
• W2912115454 hasConcept C86803240 @default.
• W2912115454 hasConceptScore W2912115454C121608353 @default.
• W2912115454 hasConceptScore W2912115454C126322002 @default.
• W2912115454 hasConceptScore W2912115454C142724271 @default.
• W2912115454 hasConceptScore W2912115454C173396325 @default.
• W2912115454 hasConceptScore W2912115454C203014093 @default.
• W2912115454 hasConceptScore W2912115454C2776107976 @default.
• W2912115454 hasConceptScore W2912115454C2776256026 @default.
• W2912115454 hasConceptScore W2912115454C2776914184 @default.
• W2912115454 hasConceptScore W2912115454C2777714996 @default.
• W2912115454 hasConceptScore W2912115454C3020616263 @default.
• W2912115454 hasConceptScore W2912115454C502942594 @default.
• W2912115454 hasConceptScore W2912115454C54355233 @default.
• W2912115454 hasConceptScore W2912115454C555283112 @default.

• next