Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912116688> ?p ?o ?g. }
- W2912116688 endingPage "16347" @default.
- W2912116688 startingPage "16338" @default.
- W2912116688 abstract "Abstract With advancing age have been observed bone and bone marrow phenotypic alterations due to the impaired bone tissue homeostatic features, involving bone remodeling, and bone marrow niche ontogeny. The complex “inflamm‐aging” pathological scenario that culminates with osteopenia and mesenchymal/stromal and hematopoietic stem cell commitment breakdown, is controlled by cellular and molecular intramural components comprising adapter proteins such as the sequestosome 1 (p62/SQSTM1). p62, a “multiway function” protein, has been reported as an effective anti‐inflammatory, bone‐building factor. In this view, we considered for the first time the involvement of p62 in aging bone and bone marrow of 1 year and 2 years p62 −/− mice. Interestingly, p62 deficiency provoked accelerated osteopenia and impaired niche operational activities within the bone marrow. The above findings unearthed the importance of p62 in mesenchymal stem cell maintenance/differentiation schedule in old animals and provide, at least in part, a mechanistic scenario of p62 action." @default.
- W2912116688 created "2019-02-21" @default.
- W2912116688 creator A5025687324 @default.
- W2912116688 creator A5026252336 @default.
- W2912116688 creator A5037434090 @default.
- W2912116688 creator A5049037510 @default.
- W2912116688 creator A5050775793 @default.
- W2912116688 creator A5051433546 @default.
- W2912116688 creator A5056335742 @default.
- W2912116688 creator A5075944770 @default.
- W2912116688 creator A5085308993 @default.
- W2912116688 date "2019-02-10" @default.
- W2912116688 modified "2023-10-01" @default.
- W2912116688 title "P62 deficiency shifts mesenchymal/stromal stem cell commitment toward adipogenesis and disrupts bone marrow homeostasis in aged mice" @default.
- W2912116688 cites W1899492786 @default.
- W2912116688 cites W1972598446 @default.
- W2912116688 cites W1975025595 @default.
- W2912116688 cites W1975733191 @default.
- W2912116688 cites W1981912182 @default.
- W2912116688 cites W1986086086 @default.
- W2912116688 cites W1987176983 @default.
- W2912116688 cites W1989772629 @default.
- W2912116688 cites W2014918593 @default.
- W2912116688 cites W2019774572 @default.
- W2912116688 cites W2022734786 @default.
- W2912116688 cites W2023598683 @default.
- W2912116688 cites W2025872915 @default.
- W2912116688 cites W2026263720 @default.
- W2912116688 cites W2028007585 @default.
- W2912116688 cites W2030458242 @default.
- W2912116688 cites W2032656636 @default.
- W2912116688 cites W2034087770 @default.
- W2912116688 cites W2037736150 @default.
- W2912116688 cites W2039874643 @default.
- W2912116688 cites W2048753210 @default.
- W2912116688 cites W2058474106 @default.
- W2912116688 cites W2062527379 @default.
- W2912116688 cites W2063254961 @default.
- W2912116688 cites W2064519035 @default.
- W2912116688 cites W2074500132 @default.
- W2912116688 cites W2087684098 @default.
- W2912116688 cites W2096738869 @default.
- W2912116688 cites W2097925548 @default.
- W2912116688 cites W2098095516 @default.
- W2912116688 cites W2100140007 @default.
- W2912116688 cites W2102354517 @default.
- W2912116688 cites W2107114877 @default.
- W2912116688 cites W2111700007 @default.
- W2912116688 cites W2113240092 @default.
- W2912116688 cites W2119399459 @default.
- W2912116688 cites W2126934086 @default.
- W2912116688 cites W2128476227 @default.
- W2912116688 cites W2130443006 @default.
- W2912116688 cites W2149841333 @default.
- W2912116688 cites W2275492483 @default.
- W2912116688 cites W2310263653 @default.
- W2912116688 cites W2374910908 @default.
- W2912116688 cites W2559461022 @default.
- W2912116688 cites W2592014417 @default.
- W2912116688 cites W2599538813 @default.
- W2912116688 cites W2600988971 @default.
- W2912116688 cites W2616240889 @default.
- W2912116688 cites W2775473419 @default.
- W2912116688 doi "https://doi.org/10.1002/jcp.28299" @default.
- W2912116688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30740681" @default.
- W2912116688 hasPublicationYear "2019" @default.
- W2912116688 type Work @default.
- W2912116688 sameAs 2912116688 @default.
- W2912116688 citedByCount "13" @default.
- W2912116688 countsByYear W29121166882019 @default.
- W2912116688 countsByYear W29121166882020 @default.
- W2912116688 countsByYear W29121166882021 @default.
- W2912116688 countsByYear W29121166882022 @default.
- W2912116688 crossrefType "journal-article" @default.
- W2912116688 hasAuthorship W2912116688A5025687324 @default.
- W2912116688 hasAuthorship W2912116688A5026252336 @default.
- W2912116688 hasAuthorship W2912116688A5037434090 @default.
- W2912116688 hasAuthorship W2912116688A5049037510 @default.
- W2912116688 hasAuthorship W2912116688A5050775793 @default.
- W2912116688 hasAuthorship W2912116688A5051433546 @default.
- W2912116688 hasAuthorship W2912116688A5056335742 @default.
- W2912116688 hasAuthorship W2912116688A5075944770 @default.
- W2912116688 hasAuthorship W2912116688A5085308993 @default.
- W2912116688 hasConcept C109159458 @default.
- W2912116688 hasConcept C122927707 @default.
- W2912116688 hasConcept C134018914 @default.
- W2912116688 hasConcept C16930146 @default.
- W2912116688 hasConcept C170033053 @default.
- W2912116688 hasConcept C198826908 @default.
- W2912116688 hasConcept C203014093 @default.
- W2912116688 hasConcept C2776541429 @default.
- W2912116688 hasConcept C2776886416 @default.
- W2912116688 hasConcept C2777083390 @default.
- W2912116688 hasConcept C2778086970 @default.
- W2912116688 hasConcept C2780007613 @default.
- W2912116688 hasConcept C28328180 @default.
- W2912116688 hasConcept C502942594 @default.
- W2912116688 hasConcept C63645605 @default.