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- W2912117310 endingPage "380" @default.
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- W2912117310 abstract "Introduction: Atopic dermatitis (AD) is the most common inflammatory skin disease, yet until recently there were no safe systemic therapies approved for the long-term management of AD in adult patients. A deeper understanding of disease pathogenesis and identification of molecular and cellular changes has resulted in a rapidly evolving pipeline of therapeutics that holds promise for safer long-term control.Areas covered: In this review, we highlight the growing arsenal of biologic and small molecule antagonists that target pathways implicated in AD pathogenesis. Evidence that AD is driven by multiple immune axes extending beyond the Th2 polarization has resulted in therapies targeting additional pathways, including the Th22, Th17/IL-23, and JAK-STAT pathways. Pruritus, a hallmark of AD, has been linked to multiple mechanisms and various therapeutics have emerged in response to alternative hypotheses.Expert opinion: Despite the assumption that AD has a common disease mechanism, recent studies indicate that the disorder is characterized by several phenotypes and therapy may need to be tailored to the unique immune traits of specific phenotypes. Targeted therapy should complement and expand our molecular map of AD across the various phenotypic iterations and help push AD pharmacotherapy into a new era of personalized medicine." @default.
- W2912117310 created "2019-02-21" @default.
- W2912117310 creator A5024365532 @default.
- W2912117310 creator A5058168360 @default.
- W2912117310 creator A5085996628 @default.
- W2912117310 date "2019-02-07" @default.
- W2912117310 modified "2023-09-25" @default.
- W2912117310 title "Current and emerging biologic and small molecule therapies for atopic dermatitis" @default.
- W2912117310 cites W1034056066 @default.
- W2912117310 cites W1501954648 @default.
- W2912117310 cites W1507534827 @default.
- W2912117310 cites W1513285467 @default.
- W2912117310 cites W1576903429 @default.
- W2912117310 cites W1577872659 @default.
- W2912117310 cites W1616393669 @default.
- W2912117310 cites W1683458702 @default.
- W2912117310 cites W1877788243 @default.
- W2912117310 cites W189068515 @default.
- W2912117310 cites W1897642281 @default.
- W2912117310 cites W1953456974 @default.
- W2912117310 cites W1963572696 @default.
- W2912117310 cites W1965139821 @default.
- W2912117310 cites W1965217362 @default.
- W2912117310 cites W1966991400 @default.
- W2912117310 cites W1968570108 @default.
- W2912117310 cites W1969725546 @default.
- W2912117310 cites W1970365072 @default.
- W2912117310 cites W1970464416 @default.
- W2912117310 cites W1973864734 @default.
- W2912117310 cites W1974644375 @default.
- W2912117310 cites W1974895367 @default.
- W2912117310 cites W1975738735 @default.
- W2912117310 cites W1978768695 @default.
- W2912117310 cites W1980432607 @default.
- W2912117310 cites W1982385791 @default.
- W2912117310 cites W1984525156 @default.
- W2912117310 cites W1986229154 @default.
- W2912117310 cites W1987389251 @default.
- W2912117310 cites W1988011157 @default.
- W2912117310 cites W1988035869 @default.
- W2912117310 cites W1992025888 @default.
- W2912117310 cites W1999306018 @default.
- W2912117310 cites W2002010381 @default.
- W2912117310 cites W2002600662 @default.
- W2912117310 cites W2002740652 @default.
- W2912117310 cites W2003774999 @default.
- W2912117310 cites W2006481910 @default.
- W2912117310 cites W2010071801 @default.
- W2912117310 cites W2010559643 @default.
- W2912117310 cites W2012077729 @default.
- W2912117310 cites W2012277454 @default.
- W2912117310 cites W2012434022 @default.
- W2912117310 cites W2012682747 @default.
- W2912117310 cites W2012868073 @default.
- W2912117310 cites W2014729966 @default.
- W2912117310 cites W2016735587 @default.
- W2912117310 cites W2017341404 @default.
- W2912117310 cites W2018126926 @default.
- W2912117310 cites W2018976775 @default.
- W2912117310 cites W2020549231 @default.
- W2912117310 cites W2021520444 @default.
- W2912117310 cites W2022877987 @default.
- W2912117310 cites W2026526625 @default.
- W2912117310 cites W2028781811 @default.
- W2912117310 cites W2029860358 @default.
- W2912117310 cites W2032062642 @default.
- W2912117310 cites W2032405768 @default.
- W2912117310 cites W2039751006 @default.
- W2912117310 cites W2039990838 @default.
- W2912117310 cites W2045189254 @default.
- W2912117310 cites W2045876119 @default.
- W2912117310 cites W2047154603 @default.
- W2912117310 cites W2047250004 @default.
- W2912117310 cites W2048138796 @default.
- W2912117310 cites W2050568107 @default.
- W2912117310 cites W2050984023 @default.
- W2912117310 cites W2057098942 @default.
- W2912117310 cites W2060307820 @default.
- W2912117310 cites W2060337740 @default.
- W2912117310 cites W2065746239 @default.
- W2912117310 cites W2067919290 @default.
- W2912117310 cites W2068097589 @default.
- W2912117310 cites W2070297069 @default.
- W2912117310 cites W2072241656 @default.
- W2912117310 cites W2073276965 @default.
- W2912117310 cites W2073404233 @default.
- W2912117310 cites W2077550414 @default.
- W2912117310 cites W2079701917 @default.
- W2912117310 cites W2082724418 @default.
- W2912117310 cites W2086831075 @default.
- W2912117310 cites W2087843772 @default.
- W2912117310 cites W2092750645 @default.
- W2912117310 cites W2092844155 @default.
- W2912117310 cites W2095224028 @default.
- W2912117310 cites W2106621815 @default.
- W2912117310 cites W2109909774 @default.
- W2912117310 cites W2114911365 @default.
- W2912117310 cites W2117564935 @default.